Complex IL1R1:IL1RAP map
Complex composition:

  1. IL1R1 map
  2. IL1RAP map

IL1R1:​IL1RAP@INNATE_IMMUNE_CELL_Membrane

Identifiers
NAME:IL1R1:IL1RAP

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / RECRUITMENT_OF_IMMUNE_CELLS  map

References
 MDSC  map
CASCADE:IL1

IL1R1:​IL1RAP@Cytosol

Identifiers
NAME:IL1R1:IL1RAP

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / INFLAMMATORY_SIGNALING_PATHWAYS  map

References
CASCADE:IL1
PMID:19161412
IL-1 signaling is initiated by the recruitment of MyD88 to the IL-1RI/IL-1RAcP complex.
The recruitment of MyD88 leads to the recruitment of IRAK1 and IRAK4, probably via their death domains. IRAK4 then activates IRAK1, allowing IRAK1 to autophosphorylate.

Modifications:
Participates in complexes:
In compartment: Cytosol
  1. IL1R1:​IL1RAP@Cytosol map
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. IL1R1:​IL1RAP@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. IL1R1:​IL1RAP@Cytosol map + MYD88@Cytosol map + IRAK4@Cytosol map → map IL1R1:​IL1RAP:​IRAK4:​MYD88@Cytosol map
  2. trILB1@default map + IL1R1:​IL1RAP@INNATE_IMMUNE_CELL_Membrane map → map IL1R1:​IL1RAP:​trILB1@INNATE_IMMUNE_CELL_Membrane map
As Catalyser: