Protein SMAD4
HUGO:SMAD4
MODULE:MACROPHAGE
MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS
PMID:11792802, PMID: 12809600
The canonical TGFB signalling pathway involves phosphorylation of the carboxy-terminal serine residue of the internal modulator SMAD proteins, SMAD2 or SMAD3, by the activated receptors. This phosphorylation induces oligomerization of SMAD2 or SMAD3 with SMAD4, which is necessary for nuclear translocation.

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Modifications:
In compartment: Cytosol

1. SMAD4@Cytosol

Participates in complexes:
In compartment: Cytosol

1. SMAD2|​pho:​SMAD4@Cytosol
2. SMAD3|​pho:​SMAD4@Cytosol

Participates in reactions:
As Reactant or Product:

1. SMAD3|​pho@Cytosol + SMAD4@Cytosol → SMAD3|​pho:​SMAD4@Cytosol
2. SMAD2|​pho@Cytosol + SMAD4@Cytosol → SMAD2|​pho:​SMAD4@Cytosol

As Catalyser:

1. gARG1@Cytosol → rARG1@Cytosol
2. STAT1@Cytosol → STAT1|​pho|​active@Cytosol
3. gNOS2@Cytosol → rNOS2@Cytosol
4. IRF3@Cytosol → IRF3|​pho@Cytosol