Protein SMAD2 map
HUGO:SMAD2
MODULE:MACROPHAGE
MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS
PMID:11792802, PMID: 12809600
The canonical TGFB signalling pathway involves phosphorylation of the carboxy-terminal serine residue of the internal modulator SMAD proteins, SMAD2 or SMAD3, by the activated receptors. This phosphorylation induces oligomerization of SMAD2 or SMAD3 with SMAD4, which is necessary for nuclear translocation.
PMID:22331441
SMAD2 and SMAD3 negatively regulate iNOS induction in macrophages by suppressing multiple steps in the IRF3-IFN-??-STAT1 pathway.
PMID:22331441
SMAD2 and SMAD3 negatively regulate iNOS induction in macrophages by suppressing multiple steps in the IRF3-IFN-??-STAT1 pathway.
TGF-??1-mediated arginase-1 induction was almost completely impaired in Smad2/3 DKO BMDMs.
Smad2 and Smad3 inhibited iNOS promoter activities and additional TGF-??1 enhanced the suppressive effect of Smads
STAT1 phosphorylation was enhanced and prolonged in Smad2/3 DKO BMDMs compared with WT BMDMs
Smad2/3 inhibited IFN-?? production by suppressing IRF3 transcriptional activity.
Smad2/3 somehow suppresses IRF3 phosphorylation.
Modifications:
In compartment: Cytosol
  1. SMAD2@Cytosol map
  2. SMAD2|​pho@Cytosol map
Participates in complexes:
In compartment: Cytosol
  1. SMAD2|​pho:​SMAD4@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. SMAD2@Cytosol map → map SMAD2|​pho@Cytosol map
  2. SMAD2|​pho@Cytosol map + SMAD4@Cytosol map → map SMAD2|​pho:​SMAD4@Cytosol map
As Catalyser:
  1. gARG1@Cytosol map → map rARG1@Cytosol map
  2. STAT1@Cytosol map → map STAT1|​pho|​active@Cytosol map
  3. gNOS2@Cytosol map → map rNOS2@Cytosol map
  4. IRF3@Cytosol map → map IRF3|​pho@Cytosol map