Protein IRF3
HUGO:IRF3
MODULE:MACROPHAGE
MODULE:CORE_SIGNALING_PATHWAYS
PMID:22331441
Smad2/3 inhibited IFN-?? production by suppressing IRF3 transcriptional activity.
Smad2/3 somehow suppresses IRF3 phosphorylation.

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Modifications:
In compartment: Cytosol

1. IRF3@Cytosol
2. IRF3|​pho@Cytosol

Participates in complexes:

Participates in reactions:
As Reactant or Product:

1. IRF3@Cytosol → IRF3|​pho@Cytosol

As Catalyser:

1. gIFNB1@Cytosol → rINFB1@Cytosol