Complex SMAD3:SMAD4 map
Complex composition:

  1. SMAD3 map
  2. SMAD4 map

SMAD3|​pho:​SMAD4@Cytosol
PMID:11792802, PMID: 12809600
The canonical TGFB signalling pathway involves phosphorylation of the carboxy-terminal serine residue of the internal modulator SMAD proteins, SMAD2 or SMAD3, by the activated receptors. This phosphorylation induces oligomerization of SMAD2 or SMAD3 with SMAD4, which is necessary for nuclear translocatio
Modifications:
Participates in complexes:
In compartment: Cytosol
  1. SMAD3|​pho:​SMAD4@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. SMAD3|​pho@Cytosol map + SMAD4@Cytosol map → map SMAD3|​pho:​SMAD4@Cytosol map
As Catalyser:
  1. gARG1@Cytosol map → map rARG1@Cytosol map
  2. STAT1@Cytosol map → map STAT1|​pho|​active@Cytosol map
  3. gNOS2@Cytosol map → map rNOS2@Cytosol map
  4. IRF3@Cytosol map → map IRF3|​pho@Cytosol map