Simple molecule L-arginine map
L-arginine@Cytosol

Identifiers

Maps_Modules

References
PMID:14568929, PMID:10925299
IL13 induces arginase activity which results in L-arginin deficiency. L-arginin deficiency impairs iNOS protein synthesis and stability.

L-arginine@default

Identifiers

Maps_Modules

References
PMID:14568929, PMID:10925299
IL13 induces arginase activity which results in L-arginin deficiency. L-arginin deficiency impairs iNOS protein synthesis and stability.
PMID:20490273, PMID:17016559
L-arginine plays a critical role in the immunosuppressive activity of MDSC. T-cell proliferation and activation depends on the availability of L-arginine. L-arginine is a nonessential amino acid and is a substrate for two enzymes, inducible NO synthase (iNOS or NOS2) and arginase 1. MDSCs express both enzymes at high levels [36]. Recent data suggests that the increased activity of arginase 1 and iNOS in MDSC leads to enhanced L-arginine catabolism, which results in a reduction or depletion of L-arginine in the microenvironment. The lack of L-arginine results in inhibition of T-cell function

Modifications:
In compartment: Cytosol
  1. L-arginine@Cytosol map
In compartment: default
  1. L-arginine@default map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. L-arginine@Cytosol map → map Urea@Cytosol map + L-ornitine@Cytosol map
    2. L-arginine@Cytosol map + O_sub_2_endsub_@Cytosol map + NADPH@Cytosol map → map NO@Cytosol map + L-citrulin@Cytosol map + NADP+@Cytosol map
    3. L-arginine@default map → map L-arginine@Cytosol map
    As Catalyser:
    1. rNOS2@Cytosol map → map NOS2@Cytosol map