Protein PTPN11 map

Identifiers
HUGO:PTPN11
protein tyrosine phosphatase, non-receptor type 11
HUGO:PTPN11 hgnc_id:HGNC:9644 HGNC:9644 ENTREZ:5781 UNIPROT:Q06124
"Noonan syndrome 1", NS1
HUGO:PTPN11 HGNC:9644 ENTREZ:5781 UNIPROT:Q06124

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / INHIBITING_CHECKPOINTS  map
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / CORE  map
 EMT Senescence  map  / CELL_CELL_ADHESIONS  map
 EMT Senescence  map  / ADHERENS_JUNCTIONS  map
 Innate Immunity  map  / IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS  map
 Innate Immunity  map  / IMMUNOSUPPPRESSIVE_CORE_PATHWAYS  map

References
PMID:11572860 PMID:15240681
CASCADE:FGF
PMID:11447289
Tyrosine-phosphorylated Shp2 molecules have not been detected in FRS2?? mutant cell lysates, indicating that FRS2?? is required for tyrosine phosphorylation of Shp2 leading to complex formation between Shp2 and Grb2. FGF-induced tyrosine phosphorylation of Shp2 as well as FRS2??/Grb2 complex formation were completely restored by ectopic expression of FRS2?? in mutant cells. These findings demonstrate that expression of functional FRS2?? is indeed crucial for the recruitment and tyrosine phosphorylation of these two effector proteins
CASCADE:KIR2DL3
CASCADE:KIR2DL2
CASCADE:KIR2DL1
CASCADE:NKG2A
CASCADE:KIR3DL1
CASCADE:KIR2DL4
CASCADE:2B4
 NATURAL_KILLER  map
 MACROPHAGE  map
PMID:19833085, PMID:15699106, PMID:12138178
Inactivation of nuclear STAT1 occurs rapidly following binding to chromatin and activation of target gene transcription.
Subsequently STAT1 is dephosphorylated by phosphatases such as PTPN2 (TCP45) and PTPN11 (SHP2), and dephosphorylated STAT1
PMID:10358138, PMID:15713798
Human 2B4 is phosphorylated following activation and recruits PTPN11 (SHP-2). Association of SAP with h2B4 prevents recruitment of SHP-2.
PMID:12707331
There is direct correlation between SHP-2 recruitment and functional inhibition of target cell conjugation and cytotoxicity downstream of KIR3DL.
PMID:9751747
KIR2DL3, KIR2DL1, KIR2DS4, KIR3DL1, KIR3DL2, KIR2DL4 interact with SHP-2 in NK cells
and probably are phosphorylated by LCK (directly demonstrated for KIR2DL3 only).
(CL6 = KIR2DL3,CL42 =KIR2DL1, CL39 = KIR2DS4, NKAT3= KIR3DL1, NKAT4 = KIR3DL2,KIR103AS=KIR2DL4) .

PTPN11@INNATE_IMMUNE_CELL_Cytosol

References
in_re709( Innate Immunity  map ):
PMID:19833085, PMID:15699106, PMID:12138178, PMID:12270932
Inactivation of nuclear STAT1 occurs rapidly following binding to chromatin and activation of target gene transcription.
Subsequently STAT1 is dephosphorylated by phosphatases such as PTPN2 (TCP45) and PTPN11 (SHP2), and dephosphorylated STAT1
returns to cytoplasm, where it can potentially serve as the substrate for subsequent rounds of activation and inactivation.
PMID:19833085
Probably, acetylation of STAT1 on lysine residues 410 and 413 in the nucleus results in enhanced interaction with TCP45 (PTPN2) and increased dephosphorylation
in_re712( Innate Immunity  map ):
PMID:19833085, PMID:15699106, PMID:15699106, PMID:15699106

Modifications:
In compartment: Cytosol
  1. PTPN11@Cytosol map
  2. PTPN11|​pho@Cytosol map
  3. PTPN11|​pho|​active@Cytosol map
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. PTPN11@INNATE_IMMUNE_CELL_Cytosol map
In compartment: T_cell
  1. PTPN11@T_cell map
Participates in complexes:
In compartment: T_cell
  1. GAB2|​pho:​PTPN11@T_cell map
  2. BTLA:​PTPN11:​PTPN6@T_cell map
  3. PDCD1:​PTPN11:​PTPN6@T_cell map
  4. KLRG1:​PTPN11:​SHIP1*@T_cell map
  5. PTPN11:​PTPN6:​PVRIG|​pho:​SHIP1*@T_cell map
Participates in reactions:
As Reactant or Product:
  1. PDCD1@T_cell map + PTPN11@T_cell map + PTPN6@T_cell map → map PDCD1:​PTPN11:​PTPN6@T_cell map
  2. BTLA@T_cell map + PTPN6@T_cell map + PTPN11@T_cell map → map BTLA:​PTPN11:​PTPN6@T_cell map
  3. PVRIG@T_cell map + SHIP1*@T_cell map + PTPN11@T_cell map + PTPN6@T_cell map → map PTPN11:​PTPN6:​PVRIG|​pho:​SHIP1*@T_cell map
  4. PTPN11@T_cell map + GAB2|​pho@T_cell map → map GAB2|​pho:​PTPN11@T_cell map
  5. PTPN11:​PTPN6:​PVRIG|​pho:​SHIP1*@T_cell map → map Tcell_prolipheration@default map
  6. KLRG1@T_cell map + PTPN11@T_cell map + SHIP1*@T_cell map → map KLRG1:​PTPN11:​SHIP1*@T_cell map
  7. BTLA:​PTPN11:​PTPN6@T_cell map → map Tcell_prolipheration@default map
  8. PTPN11@Cytosol map → map PTPN11|​pho@Cytosol map
  9. PTPN11@Cytosol map → map PTPN11|​pho|​active@Cytosol map
  10. PTPN11@INNATE_IMMUNE_CELL_Cytosol map → map PTPN11@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. CD226@T_cell map → map CD226|​pho|​active@T_cell map
  2. CD247|​pho:​CD3*|​pho:​alpha_/beta_TCR*@cSMAC map → map CD247:​CD3*:​alpha_/beta_TCR*@cSMAC map
  3. gIL2@T_cell map → map rIL2@T_cell map
  4. rIL2@T_cell map → map IL2@T_cell map
  5. gCXCL8@T_cell map → map rCXCL8@T_cell map
  6. gTNF@T_cell map → map rTNF@T_cell map
  7. gIFNG@T_cell map → map rIFNG@T_cell map
  8. rIFNG@T_cell map → map IFNG@T_cell map
  9. rIL10@T_cell map → map IL10@T_cell map
  10. gCK2@T_cell map → map rCK2*@T_cell map
  11. rIL5@T_cell map → map IL5@T_cell map
  12. rIL13@T_cell map → map IL13@T_cell map
  13. gIL6@T_cell map → map rIL6@T_cell map
  14. gIL1B@T_cell map → map rIL1B@T_cell map
  15. GRB2@Cytosol map → map GRB2@Cytosol map
  16. FAK1*|​Y_pho|​pho|​active@Cytosol map → map FAK1*|​pho@Cytosol map
  17. STAT1|​pho|​ace@INNATE_IMMUNE_CELL_Cytosol map → map STAT1|​ace@INNATE_IMMUNE_CELL_Cytosol map
  18. STAT1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map → map STAT1@INNATE_IMMUNE_CELL_Cytosol map