Antisense RNA MIR378
Identifiers
HUGO:MIR378
microRNA 378
HUGO:MIR378 GENECARDS:MIR378 KEGG:494327 WIKI:MIR378
Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
Innate Immunity
/ MIRNA_TF_IMMUNOSUPPRESSIVE
HMC:EVADING_GROWTH_SUPPRESSORS
Survival
/ HEDGEHOG
References
NATURAL_KILLER
CASCADE:IFNAB
PMID:22649192
miR-378 and miR-30e are markedly decreased in activated NK cells by IFNA,
miR-378 and miR-30e directly targeted granzyme B and perforin, respectively and suppress of human NK cell cytotoxicity..
PMID:19446450
PMID:18077375
arMIR378@Nucleus
References
s_shh2_re122:( Survival
) PMID:19351822
s_shh2_re159:( Survival
) PMID:18077375
Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
- arMIR378@INNATE_IMMUNE_CELL_Cytosol
In compartment: Nucleus
- arMIR378@Nucleus
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
- GZMB:MIR378@INNATE_IMMUNE_CELL_Cytosol
In compartment: Nucleus
- FUS:MIR378@Nucleus
- FUS:MIR378@Nucleus
- MIR378:SUFU@Nucleus
Participates in reactions:
As Reactant or Product:- gMIR378@INNATE_IMMUNE_CELL_Cytosol
→
arMIR378@INNATE_IMMUNE_CELL_Cytosol
- arMIR378@INNATE_IMMUNE_CELL_Cytosol
+ rGZMB@INNATE_IMMUNE_CELL_Cytosol
→
GZMB:MIR378@INNATE_IMMUNE_CELL_Cytosol
- GZMB:MIR378@INNATE_IMMUNE_CELL_Cytosol
→
degraded
- rSUFU@Nucleus
+ arMIR378@Nucleus
→
MIR378:SUFU@Nucleus
- arMIR378@Nucleus
+ rFUS@Nucleus
→
FUS:MIR378@Nucleus
- gMIR378@Nucleus
→
arMIR378@Nucleus
- arMIR378@Nucleus
+ rFUS@Nucleus
→
FUS:MIR378@Nucleus
- arMIR378@Nucleus
+ rSUFU@Nucleus
→
MIR378:SUFU@Nucleus
As Catalyser: