Protein VE-Cadherin* map

Identifiers
HUGO:CDH5
cadherin 5, type 2 (vascular endothelium)
HUGO:CDH5, HGNC:1764, ENTREZ:1003, UNIPROT:P33151, GENECARDS:GC16P066400????

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CELL_CELL_ADHESIONS  map
 EMT Senescence  map  / ADHERENS_JUNCTIONS  map

References
PMID:22975327
PMID:10685062
Adherens junctions are ubiquitously expressed in endothelia of all vascular beds?
Adherens junction in endothelila cells are formed by homofilic binding of VE-cahderin (cadherin-5)
Cadherins are cell adhesion molecules anchored by their cytoplasmic tails to a network of intracellular cytoplasmic proteins connected to the actin-based microfilament system.
Association with catenins is nessesary for cadherin-mediated cell adhesion.
PMID:12426320
VE-cadhein interacts with catenin delta 1 (p120-catenin, CTNND1)
VE-cadhein interacts with Plakophilin 4 (PKP4)
PMID:7962210
VE-cadhein interacts with catenin beta 1 (CTNNB1)
PKP4 and CTNND1 bind to the same region on the cytoplasmic tail of VE-cadherin.
Overexpression of PKP4 can displace CTNND1 from intercellular junctions.
PMID:9739078
VE-cadhein interacts with Plakoglobin (JUP)

Modifications:
In compartment: Cytosol
  1. VE-Cadherin*@Cytosol map
In compartment: Neighbouring Cell
  1. VE-Cadherin*@Neighbouring Cell map
Participates in complexes:
In compartment: Cytosol
  1. VE-Cadherin*:​_beta_-Catenin*_p120*1_Plakoglobin*_Plakophilin4*@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. VE-Cadherin*@Cytosol map → map internalization@Cytosol map
  2. S1PR*:​Sphingosine-1-phosphate@Extracellular Matrix map → map VE-Cadherin*@Cytosol map
  3. VE-Cadherin*@Cytosol map + _beta_-Catenin*_p120*1_Plakoglobin*_Plakophilin4*@Cytosol map → map VE-Cadherin*:​_beta_-Catenin*_p120*1_Plakoglobin*_Plakophilin4*@Cytosol map
  4. VE-Cadherin*:​_beta_-Catenin*_p120*1_Plakoglobin*_Plakophilin4*@Cytosol map → map Desmosomes@Cytosol map
  5. Plakoglobin binding partners*@Cytosol map → map VE-Cadherin*@Cytosol map
  6. Cadherin*@Cytosol map → map VE-Cadherin*@Cytosol map
  7. VE-Cadherin*@Neighbouring Cell map + VE-Cadherin*@Cytosol map → map em_s2504
As Catalyser: