Identifiers
ligase IV, DNA, ATP-dependent
HUGO:LIG4, HGNC:6601, ENTREZ:3981, UNIPROT:P49917

Maps_Modules
HMC:GENOME_INSTABILITY_AND_MUTATION
 Cell Cycle DNA Repair   / C_NHEJ 

References
PMID:20691907, PMID:12471202, PMID:19772495, PMID:19346677, PMID:15703371, PMID:19847258, PMID:16697054, PMID:19473888, PMID:19808869

1. LIG4@Nucleus

1. LIG4:​PNK*:​XRCC4@Nucleus
2. LIG4:​XLF*:​XRCC4|​hm2@Nucleus
3. APLF:​Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho:​DNA-PK*|​hm2:​Ku70*:​Ku80*:​LIG4:​PARP3:​XLF*:​XRCC4|​hm2@Nucleus

1. XRCC4@Nucleus + LIG4@Nucleus + PNK*@Nucleus → LIG4:​PNK*:​XRCC4@Nucleus
2. Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho|​active@Nucleus + LIG4:​XLF*:​XRCC4|​hm2@Nucleus + PARP3@Nucleus + DNA-PK*|​hm2|​active@Nucleus + Ku80*@Nucleus + Ku70*@Nucleus + APLF@Nucleus → APLF:​Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho:​DNA-PK*|​hm2:​Ku70*:​Ku80*:​LIG4:​PARP3:​XLF*:​XRCC4|​hm2@Nucleus
3. XRCC4|​hm2@Nucleus + LIG4@Nucleus + XLF*@Nucleus → LIG4:​XLF*:​XRCC4|​hm2@Nucleus

1. gC_NHEJ_DNA_st2*@Nucleus → gC_NHEJ_DNA_st3*@Nucleus
2. gC_NHEJ_DNA_st4*@Nucleus → gC_NHEJ_DNA_st5*@Nucleus