Complex MDM2:p53* map
Complex composition:

  1. p53* map
  2. MDM2 map

MDM2|​S186_pho:​p53*@Nucleus

Identifiers
NAME:MDM2:p53*

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map

References
PMID:15140942
Phosphorylations on p53 prevent its binding to MDM2.
PMID:15574337
S186 phosphorylation of MDM2 by AKT favors the binding of MDM2 to p53 and its following degradation.
em_emtc_emtc_re1213( EMT Senescence  map ):
PMID:19336515
TWIST1 physically promotes interaction between p53 and MDM2
em_emtc_emtc_re1214( EMT Senescence  map ):
PMID:9819415
Nuclear exports is required for degradation of p53 by MDM2
em_emtc_emtc_re1216( EMT Senescence  map ):
PMID:19448627
Complex of p53, MDM2 and Slug faciliates the proteasomal degradation of Slug by MDM2.

MDM2|​S186_pho:​p53*@Cytosol

Identifiers
NAME:MDM2:p53*

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map

References
PMID:15140942
Phosphorylations on p53 prevent its binding to MDM2.
PMID:15574337
S186 phosphorylation of MDM2 by AKT favors the binding of MDM2 to p53 and its following degradation.
em_emtc_emtc_re1214( EMT Senescence  map ):
PMID:9819415
Nuclear exports is required for degradation of p53 by MDM2

Modifications:
Participates in complexes:
In compartment: Cytosol
  1. MDM2|​S186_pho:​p53*@Cytosol map
In compartment: Nucleus
  1. MDM2|​S186_pho:​p53*@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. p53*@Nucleus map + MDM2|​S186_pho@Nucleus map → map MDM2|​S186_pho:​p53*@Nucleus map
  2. MDM2|​S186_pho:​p53*@Nucleus map → map MDM2|​S186_pho:​p53*@Cytosol map
  3. MDM2|​S186_pho:​p53*@Cytosol map → map degraded
  4. SNAI2@Nucleus map + MDM2|​S186_pho:​p53*@Nucleus map → map MDM2|​S186_pho:​SNAI2:​p53*@Nucleus map
  5. MDM2|​S186_pho:​p53*@Nucleus map → map degraded
As Catalyser: