Reaction heterodimer_association em_emtc_emtc_re1213 map

p53*@Nucleus map + MDM2|​S186_pho@Nucleus map → MDM2|​S186_pho:​p53*@Nucleus map

Reaction regulators:
Physical_stimulation
  1. TWIST1|​S68_pho@Nucleus map


References
PMID:15140942
Phosphorylations on p53 prevent its binding to MDM2.
PMID:15574337
S186 phosphorylation of MDM2 by AKT favors the binding of MDM2 to p53 and its following degradation.
PMID:19336515
TWIST1 physically promotes interaction between p53 and MDM2