Identifiers
macrophage migration inhibitory factor
HUGO:MIF hgnc_id:HGNC:7097 HGNC:7097 ENTREZ:4282 UNIPROT:P14174
macrophage migration inhibitory factor (glycosylation-inhibiting factor)
HUGO:MIF HGNC:7097 ENTREZ:4282 UNIPROT:P14174
HUGO:MIF

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts   / GROWTH_FACTORS_SIGNALING_PATHWAYS 
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / APOPTOSIS 
 Innate Immunity   / IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS 

References
CASCADE:MIF
PMID:12782713
CD74 mediates MIF stimulation of ERK-1/2 (p44/p42) phosphorylation and proliferation of CCL210 human lung fibroblasts.
PMID:20861157
MIF inhibits in CXCR2/CD74-dependent manner recruitment of CAFs to the growing tumor.
 MACROPHAGE 
 MDSC 
 NATURAL_KILLER 
CASCADE:TNF
CASCADE:IFNG
CASCADE:IL4
CASCADE:IL13
CASCADE:TLR2_4
PMID:9637476, PMID:10878343
MIF prevented the release of perforin granules by NK cells but not CTLs.
Tumor cells produce Macrophage Migration-Inhibitory Factor to Prevent Lysis by NK Cells.
PMID:18490733
MIF inhibits NK cell activity through a transcriptional down-regulation of NKG2D
PMID:16283355, PMID:12803886
MIF upregulates expression of TLR4 in macrothages via PU.1 (SPI1) activation
MIF signal transduction initiated by binding to CD74.
PMID:23390297
MIF deficiency or small-molecule inhibition reduces splenic MDSC immune suppression in tumor-bearing mice
PMID:8195715
TNF and INFG induce MIF secretion in macrophages, TLR4 signaling induces MIF expression.
MIF inhitits expression of M1 markers such as TNF, IL12p40, COX2, INOS, IRF-5, MHC-II, CD11c, CD80, CD86 and MIF induces expression of M2 markers as IL10, stabilin-1, MRC-1, CD23

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / APOPTOSIS 

References
rc_re431( Regulated Cell Death  ):
PMID:18677096
>From abstract (no acces to the article)
interaction BIM (all 3 major isoforms) - MIF in vitro and in HEK293 and K562 immortalised human myelogenous leukaemia cell line (bcr:abl positive).
MIF displays negative effect on BIM mediated apoptosis when over-expressed.
MIF targeting siRNA in K562 increases diamide-induced apoptosis.

1. MIF@Cytosol

1. MIF@INNATE_IMMUNE_CELL_Cytosol

1. MIF@default

1. CD74:​MIF@Cytosol

1. CD74:​MIF@INNATE_IMMUNE_CELL_Membrane

1. MIF@default + CD74@Cytosol → CD74:​MIF@Cytosol
2. MIF@default → MIGRATION_INTO_THE_TUMOR@default
3. rMIF@INNATE_IMMUNE_CELL_Cytosol → MIF@INNATE_IMMUNE_CELL_Cytosol
4. MIF@INNATE_IMMUNE_CELL_Cytosol → MIF@default
5. MIF@default + CD74@INNATE_IMMUNE_CELL_Membrane → CD74:​MIF@INNATE_IMMUNE_CELL_Membrane
6. BCL2L11|​ubi@Cytosol + MIF@Cytosol → rc_s220

1. ERK1/2*@Cytosol → ERK1/2*|​pho@Cytosol
2. gTNF@INNATE_IMMUNE_CELL_Cytosol → rTNF@INNATE_IMMUNE_CELL_Cytosol
3. gMRC1@MARKERS_MACROPHAGE → rMRC1@MARKERS_MACROPHAGE
4. gSTAB1@MARKERS_MACROPHAGE → rSTAB1@MARKERS_MACROPHAGE
5. gFCER2@MARKERS_MACROPHAGE → rFCER2@MARKERS_MACROPHAGE
6. CD11c*@INNATE_IMMUNE_CELL_Cytosol → CD11c*@INNATE_IMMUNE_CELL_Membrane
7. PRF1@SECRETORY_GRANULE → PRF1@default
8. ERK1/2*@INNATE_IMMUNE_CELL_Cytosol → ERK1/2*|​pho@INNATE_IMMUNE_CELL_Cytosol
9. gNKG2D*@INNATE_IMMUNE_CELL_Cytosol → rNKG2D*@INNATE_IMMUNE_CELL_Cytosol
10. CD80@INNATE_IMMUNE_CELL_Cytosol → CD80@INNATE_IMMUNE_CELL_Membrane
11. CD86@INNATE_IMMUNE_CELL_Cytosol → CD86@INNATE_IMMUNE_CELL_Membrane
12. gIL10@INNATE_IMMUNE_CELL_Cytosol → rIL10@INNATE_IMMUNE_CELL_Cytosol
13. gNOS2@INNATE_IMMUNE_CELL_Cytosol → rNOS2@INNATE_IMMUNE_CELL_Cytosol
14. gIL12p40*@INNATE_IMMUNE_CELL_Cytosol → rIL12p40*@INNATE_IMMUNE_CELL_Cytosol
15. gMMP9@INNATE_IMMUNE_CELL_Cytosol → rMMP9@INNATE_IMMUNE_CELL_Cytosol
16. gMHC class II*@INNATE_IMMUNE_CELL_Cytosol → rMHC class II*@INNATE_IMMUNE_CELL_Cytosol
17. gVEGFA@INNATE_IMMUNE_CELL_Cytosol → rVEGFA@INNATE_IMMUNE_CELL_Cytosol
18. SPI1@INNATE_IMMUNE_CELL_Cytosol → SPI1@INNATE_IMMUNE_CELL_Cytosol
19. gIRF5@INNATE_IMMUNE_CELL_Cytosol → rIRF5@INNATE_IMMUNE_CELL_Cytosol
20. gPTGS2@INNATE_IMMUNE_CELL_Cytosol → rPTGS2@INNATE_IMMUNE_CELL_Cytosol
21. PGE2@INNATE_IMMUNE_CELL_Cytosol → PGE2@default