Protein FGFR3-ligands* map

Identifiers
fibroblast growth factor 1 (acidic)
HUGO:FGF1, HGNC:3665, ENTREZ:2246, GENECARDS:GC05M141953, UNIPROT:P05230
fibroblast growth factor 2 (basic)
FGFB
HUGO:FGF2 HGNC:3676 ENTREZ:2247 UNIPROT:P09038
fibroblast growth factor 8 (androgen-induced)
HUGO:FGF8 HGNC:3686 ENTREZ:2253 UNIPROT:P55075
"fibroblast growth factor 9 (glia-activating factor)"
HUGO:FGF9 HGNC:3687 ENTREZ:2254 UNIPROT:P31371

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / ECM  map

References
PMID:14517404
Fibroblast growth factor FGF1, a prototypic member of the FGF family, has the ability to stimulate angiogenesis in an in vivo model of angiogenesis.
Eggs received secreted FGF1 showed a significant increase in vascularization when compared to eggs received vector alone plasmids.
PMID:16272825
This FGF1-mediated angiogenesis involves in the PI3K/AKT pathway.
Blocked PI3K pathway via LY294002 in FGF1-transfected CAMs (chicken chorio- allantoic membrane) signifi cantly inhibited angiogenesis
PMID:16682805
Both activity and mRNA expression levels of the Ets1 molecule were increased in response to FGF1 overexpression
Ets-1 activation is a requisite for FGF1-mediated angiogenesis in vivo.

Modifications:
In compartment: Extracellular space
  1. FGFR3-ligands*@Extracellular space map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. FGFR3-ligands*@Extracellular space map → map FGF1@Extracellular space map
    2. FGFR3-ligands*@Extracellular space map → map FGF2@Extracellular space map
    3. FGFR3-ligands*@Extracellular space map → map FGF8@Extracellular space map
    4. FGFR3-ligands*@Extracellular space map → map FGF9@Extracellular space map
    5. FGF family*@Extracellular space map → map FGFR3-ligands*@Extracellular space map
    As Catalyser: