Protein FGFR4-ligands* map

Identifiers
fibroblast growth factor 1 (acidic)
HUGO:FGF1, HGNC:3665, ENTREZ:2246, GENECARDS:GC05M141953, UNIPROT:P05230
fibroblast growth factor 2 (basic)
FGFB
HUGO:FGF2 HGNC:3676 ENTREZ:2247 UNIPROT:P09038
fibroblast growth factor 6
HUGO:FGF6 HGNC:3684 ENTREZ:2251 UNIPROT:P10767
fibroblast growth factor 16
HUGO:FGF16 HGNC:3672 ENTREZ:8823 UNIPROT:O43320
fibroblast growth factor 19
HUGO:FGF19 HGNC:3675 ENTREZ:9965 UNIPROT:O95750

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / ECM  map

References
PMID:14517404
Fibroblast growth factor FGF1, a prototypic member of the FGF family, has the ability to stimulate angiogenesis in an in vivo model of angiogenesis.
Eggs received secreted FGF1 showed a significant increase in vascularization when compared to eggs received vector alone plasmids.
PMID:16272825
This FGF1-mediated angiogenesis involves in the PI3K/AKT pathway.
Blocked PI3K pathway via LY294002 in FGF1-transfected CAMs (chicken chorio- allantoic membrane) signifi cantly inhibited angiogenesis
PMID:16682805
Both activity and mRNA expression levels of the Ets1 molecule were increased in response to FGF1 overexpression
Ets-1 activation is a requisite for FGF1-mediated angiogenesis in vivo.

Modifications:
In compartment: Extracellular space
  1. FGFR4-ligands*@Extracellular space map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. FGFR4-ligands*@Extracellular space map → map FGF1@Extracellular space map
    2. FGFR4-ligands*@Extracellular space map → map FGF2@Extracellular space map
    3. FGFR4-ligands*@Extracellular space map → map FGF6@Extracellular space map
    4. FGFR4-ligands*@Extracellular space map → map FGF16@Extracellular space map
    5. FGFR4-ligands*@Extracellular space map → map FGF19@Extracellular space map
    6. FGF family*@Extracellular space map → map FGFR4-ligands*@Extracellular space map
    As Catalyser: