Identifiers
fibroblast growth factor 1 (acidic)
HUGO:FGF1, HGNC:3665, ENTREZ:2246, GENECARDS:GC05M141953, UNIPROT:P05230
fibroblast growth factor 2 (basic)
FGFB
HUGO:FGF2 HGNC:3676 ENTREZ:2247 UNIPROT:P09038
fibroblast growth factor 3
"fibroblast growth factor 3 (murine mammary tumor virus integration site (v-int-2) oncogene homolog)",
INT2, HBGF-3, "INT-2 proto-oncogene protein", "murine mammary tumor virus integration site 2, mouse",
HUGO:FGF3 HGNC:3681 ENTREZ:2248 UNIPROT:P11487
fibroblast growth factor 4
"heparin secretory transforming protein 1", HSTF1
HUGO:FGF4 HGNC:3682 ENTREZ:2249 UNIPROT:P08620
fibroblast growth factor 10
HUGO:FGF10 HGNC:3666 ENTREZ:2255 UNIPROT:O15520
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / ECM
References
PMID:14517404
Fibroblast growth factor FGF1, a prototypic member of the FGF family, has the ability to stimulate angiogenesis in an in vivo model of angiogenesis.
Eggs received secreted FGF1 showed a significant increase in vascularization when compared to eggs received vector alone plasmids.
PMID:16272825
This FGF1-mediated angiogenesis involves in the PI3K/AKT pathway.
Blocked PI3K pathway via LY294002 in FGF1-transfected CAMs (chicken chorio- allantoic membrane) signifi cantly inhibited angiogenesis
PMID:16682805
Both activity and mRNA expression levels of the Ets1 molecule were increased in response to FGF1 overexpression
Ets-1 activation is a requisite for FGF1-mediated angiogenesis in vivo.
→ FGF1@Extracellular space
→ FGF2@Extracellular space
→ FGF3@Extracellular space
→ FGF4@Extracellular space
→ FGF10@Extracellular space
→ FGFR1-ligands*@Extracellular space
→ FGFR1-ligands*@Extracellular space