Protein Rac1_GEFs* map

Identifiers
Rac1_GEFs*
Rho/Rac guanine nucleotide exchange factor (GEF) 2
HUGO:ARHGEF2, HGNC:682, ENTREZ:9181, GENECARDS:GC01M155916, UNIPROT:Q92974
Rho guanine nucleotide exchange factor (GEF) 4
HUGO:ARHGEF4, HGNC:684, ENTREZ:50649, GENECARDS:GC02P131595, UNIPROT:Q9NR80
epithelial cell transforming sequence 2 oncogene
HUGO:ECT2, HGNC:3155, ENTREZ:1894, GENECARDS:GC03P172468, UNIPROT:Q9H8V3
RAP1, GTP-GDP dissociation stimulator 1
HUGO:RAP1GDS1, HGNC:9859, ENTREZ:5910, GENECARDS:GC04P099182, UNIPROT:P52306
vav 2 guanine nucleotide exchange factor
HUGO:VAV2, HGNC:12658, ENTREZ:7410, GENECARDS:GC09M136627, UNIPROT:P52735
vav 1 guanine nucleotide exchange factor
HUGO:VAV1, HGNC:12657, ENTREZ:7409, GENECARDS:GC19P006772, UNIPROT:P15498
MCF.2 cell line derived transforming sequence
HUGO:MCF2 HGNC:6940 ENTREZ:4168 UNIPROT:P10911
differentially expressed in FDCP 6 homolog (mouse)
"differentially expressed in FDCP (mouse homolog) 6"
HUGO:DEF6 HGNC:2760 ENTREZ:50619 UNIPROT:Q9H4E7
T-cell lymphoma invasion and metastasis 1
HUGO:TIAM1 HGNC:11805 ENTREZ:7074 UNIPROT:Q13009

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CYTOSKELETON_POLARITY  map

Rac1_GEFs*@Cytosol

References
em_emtc_emtc_re756( EMT Senescence  map ):
PMID:16371504
The endocytosis of trans-interacting E-cadherin was inhibited by Rac and Cdc42 small G proteins, which were activated by trans-interacting E-cadherin.
em_emtc_emtc_re823( EMT Senescence  map ):
VAV1,2 are GEFs for Rac1.
PMID:11080163
VAV2 is recruited by the CD19 co-receptor of the B cells and participates in the B cell receptor signaling.
PMID:12165654
in the T cell, VAV1 forms complex with LCP2.
This complex is involved in the T cell receptor and CD28 signaling cascades.
em_emtc_emtc_re828( EMT Senescence  map ):
PMID:11394904
PMID:10652228
GEF activity of MCF2 (DBL) towards CDC42 or Rac1 is enhanced upon TNK2 (ACK1) phosphorylation.
em_emtc_emtc_re982( EMT Senescence  map ):
PMID:15308668
DOCK1 (so-called DOCK180) is a GEF of Rac1.
DOCK1 together with paxillin-Crk constitutes the main pathway transducing collagen-mediated signals for the activation of Rac1.
This signaling pathway is down-regulated when cell migration is counteracted by C3G/Rap1 activation.
A balance between Rac1 and Rap1 GTPases in controlling the migratory versus the stationary state of the cell is suggested.
PMID:12432077
DOCK1 is a GEF for Rac1 and possibly for CDC42
PMID:9808620
DOCK1 is involved in integrin signaling through Crk-p130Cas complexes.
DOCK1 activates JNK in a Rac1, Cdc42 - dependent manner
Overexpression of DOCK1 increases the amount of GTP-bound Rac1
Coexpression of Crk2 and p130Cas (BCAR1) enhances this DOCK1-dependent activation of Rac1.
Direct binding of DOCK1 to Rac1, but not to RhoA or Cdc42.
To sum up, DOCK1 is a novel activator of Rac1 and involved in integrin signaling.

Modifications:
In compartment: Cytosol
  1. Rac1_GEFs*@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. Rac1_GEFs*@Cytosol map → map VAV1@Cytosol map
    2. Rac1_GEFs*@Cytosol map → map VAV2@Cytosol map
    3. Rac1_GEFs*@Cytosol map → map ARHGEF2@Cytosol map
    4. Rac1_GEFs*@Cytosol map → map ARHGEF4@Cytosol map
    5. Rac1_GEFs*@Cytosol map → map ARHGEF31*@Cytosol map
    6. Rac1_GEFs*@Cytosol map → map MCF2|​pho|​active@Cytosol map
    7. Rac1_GEFs*@Cytosol map → map RAP1GDS1@Cytosol map
    8. Rac1_GEFs*@Cytosol map → map DEF6@Cytosol map
    9. Rac1_GEFs*@Cytosol map → map TIAM1@Cytosol map
    10. Rac1_GEFs*@Cytosol map → map DOCK1@Cytosol map
    As Catalyser:
    1. GDP:​RAC1@Cytosol map → map GTP:​RAC1@Cytosol map