Identifiers
epithelial cell transforming sequence 2 oncogene
HUGO:ECT2, HGNC:3155, ENTREZ:1894, GENECARDS:GC03P172468, UNIPROT:Q9H8V3
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / CYTOSKELETON_POLARITY
References
PMID:10579713
Human ECT2 (so-called ARHGEF31)is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis.
PMID:10837491
The level of GTP-Rho did not change significantly from the S phase to the prometaphase, but increased thereafter, peaking in the telophase, and returned to the original level in the G1 phase.
Expression of the dominant negative form of ECT2 completely suppressed both the rise of GTP-Rho in the telophase and the increased GDP-GTP exchange activity in the mitotic cell extracts.
These results suggest a critical role of ECT2 in Rho activation during cytokinesis
References
em_emtc_emtc_re890( EMT Senescence ):
PMID:8836113
GEFs are essential for CDC42 activation. They promote the exchange of GDP to GTP to generate the activated form of CDC42 capable of recognizing downstram targets.
PMID:10579713
ARHGEF31 as a GEF of CDC42
→ ARHGEF31*@Cytosol
→ ARHGEF31*@Cytosol
→ ARHGEF31*@Cytosol