Identifiers
Rho/Rac guanine nucleotide exchange factor (GEF) 2
HUGO:ARHGEF2, HGNC:682, ENTREZ:9181, GENECARDS:GC01M155916, UNIPROT:Q92974
HUGO:ARHGEF2
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / CYTOSKELETON_POLARITY
References
PMID:18287519
GEF-H1(so-called ARHGEF2) is a microtubule-associated guanine nucleotide exchange factor that activates RhoA upon release from microtubules.
DENDRITIC_CELL
PMID:16917499
TIKAM1(TRIF) is an adaptor of TLR signaling, TLR signaling via ARHGEF2 (GEFH1)and RHOB regulates MHCII surface expression.
Just TRIF-dependent but Myd88-independent pathway enhanced the RhoB activity in DC after LPS stimulation.
References
em_emtc_emtc_re730( EMT Senescence ):
PMID:9857026
GEF-H1 is so-called ARHGEF2
GEFH1, which associates with tubulin in a manner dependent on a Zn-finger motif, is a regulator of the Rho family
GEFH1 is known to activate Rho A, B, C, and Rac1 but is inactive toward Cdc42, TC10, or Ras.
GEFH1 may have a direct role in activation of Rac and/or Rho and in bringing the activated GTPase to specific target sites such as microtubules.
PMID:16917499
The activation of GEFH1- RhoB through the TRIF-dependent pathway of LPS in DC might be a critical target for controlling the activation of CD4+ T cells.