Protein MCF2 map

Identifiers
MCF.2 cell line derived transforming sequence
HUGO:MCF2 HGNC:6940 ENTREZ:4168 UNIPROT:P10911

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CYTOSKELETON_POLARITY  map

References
PMID:11394904
PMID:10652228
GEF activity of MCF2 (DBL) towards CDC42 or Rac1 is enhanced upon TNK2 (ACK1) phosphorylation.
PMID:18470881
Nm23-H1 binds Dbl-1 and thus interferes with the ability of Dbl-1 to load GTP onto CDC42

MCF2@Cytosol

References
em_emtc_emtc_re838( EMT Senescence  map ):
PMID:11394904
PMID:10652228
GEF activity of MCF2 (DBL) towards CDC42 or Rac1 is enhanced upon TNK2 (ACK1) phosphorylation.
PMID:18470881
Nm23-H1 binds Dbl-1 and thus interferes with the ability of Dbl-1 to load GTP onto CDC42

MCF2|​pho|​active@Cytosol

References
em_emtc_emtc_re828( EMT Senescence  map ):
PMID:11394904
PMID:10652228
GEF activity of MCF2 (DBL) towards CDC42 or Rac1 is enhanced upon TNK2 (ACK1) phosphorylation.
em_emtc_emtc_re838( EMT Senescence  map ):
PMID:18470881
Nm23-H1 binds Dbl-1 and thus interferes with the ability of Dbl-1 to load GTP onto CDC42
em_emtc_emtc_re891( EMT Senescence  map ):
PMID:8836113
GEFs are essential for CDC42 activation. They promote the exchange of GDP to GTP to generate the activated form of CDC42 capable of recognizing downstram targets.
PMID:10843989
MCF2 (DBL) as a GEF of CDC42

Modifications:
In compartment: Cytosol
  1. MCF2@Cytosol map
  2. MCF2|​pho|​active@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. Rac1_GEFs*@Cytosol map → map MCF2|​pho|​active@Cytosol map
    2. MCF2@Cytosol map → map MCF2|​pho|​active@Cytosol map
    3. CDC42_GEFs*@Cytosol map → map MCF2|​pho|​active@Cytosol map
    As Catalyser: