Reaction state_transition ce_re37 map

ATR@Nucleus map → ATR|​pho|​active@Nucleus map

Reaction regulators:
Boolean_logic_gate_and
  1. MLH1:​PMS2@Nucleus map and MSH2|​pho:​MSH6|​pho@Nucleus map
Physical_stimulation
  1. gFanconi_DNA_st1*@Nucleus map
  2. MSH2|​pho:​MSH6|​pho@Nucleus map
  3. MLH1:​PMS2@Nucleus map
Trigger
  1. gOxidized_ring-saturated_hydrolysed_base*@Nucleus map
  2. gDeaminated_alkylated_mismatched_base*@Nucleus map


References
PMID:16332722, PMID:15136767
ATR binds stalled fork and phosphorylates CHK1 that activates checkpoint, stops cell cycle