Protein RHEB map

Identifiers
HUGO:HREB
HUGO:RHEB
Ras homolog enriched in brain
HUGO:RHEB HGNC:10011 ENTREZ:6009 UNIPROT:Q15382
HUGO:RHEB HGNC:10011 ENTREZ:6009 UNIPROT:Q15382 GENECARDS:RHEB REACTOME:63056 KEGG:6009 ATLASONC:GC_RHEB WIKI:RHEB
Q15382

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / TCR_SIGNALING  map
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / STARVATION_AUTOPHAGY  map
 Innate Immunity  map  / IMMUNOSTIMULATORY_CORE_PATHWAYS  map
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / PI3K_AKT_MTOR  map

References
PMID:12906785 PMID:19022819 PMID:23087689
 DENDRITIC_CELL  map
 NATURAL_KILLER  map
PMID:12906785, PMID:19022819
AKT activates Rapamycin associated protein FRAP2 ( mTOR ) probably through Tuberin/GTP-binding protein Ras homolog enriched in brain ( RHEB ) pathway.
PMID:19143635
PMID:18466115

RHEB@Endosome Membrane

References
s_akt1_re37( Survival  map ):
PMID:16636147
ANNOTATION:THE PHOSPHORYLATION STATE OF TSC2 IS NOT OFF INFLUENCE ON THE GTPase ACTIVITY OF THE PROTEIN

RHEB|​pho@Endosome Membrane

References
s_akt1_re37( Survival  map ):
PMID:16636147
ANNOTATION:THE PHOSPHORYLATION STATE OF TSC2 IS NOT OFF INFLUENCE ON THE GTPase ACTIVITY OF THE PROTEIN
s_akt1_re61:( Survival  map ) PMID:17604271

Modifications:
In compartment: Endosome Membrane
  1. RHEB@Endosome Membrane map
  2. RHEB|​pho@Endosome Membrane map
Participates in complexes:
In compartment: Cytosol
  1. BNIP3:​RHEB@Cytosol map
  2. FKBP8:​RHEB|​pre@Cytosol map
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. GDP:​RHEB@INNATE_IMMUNE_CELL_Cytosol map
  2. (GTP:​RHEB)|​active@INNATE_IMMUNE_CELL_Cytosol map
In compartment: Lysosome
  1. GDP:​RHEB@Lysosome map
  2. GTP:​RHEB@Lysosome map
In compartment: T_cell
  1. GDP:​RHEB@T_cell map
  2. (GTP:​RHEB)|​active@T_cell map
Participates in reactions:
As Reactant or Product:
  1. (GTP:​RHEB)|​active@T_cell map + GDP@T_cell map → map GDP:​RHEB@T_cell map + GTP@T_cell map
  2. (GTP:​RHEB)|​active@INNATE_IMMUNE_CELL_Cytosol map + GDP@INNATE_IMMUNE_CELL_Cytosol map → map GDP:​RHEB@INNATE_IMMUNE_CELL_Cytosol map + GTP@INNATE_IMMUNE_CELL_Cytosol map
  3. GDP:​RHEB@Lysosome map → map GTP:​RHEB@Lysosome map
  4. GTP:​RHEB@Lysosome map → map GDP:​RHEB@Lysosome map
  5. rc_s4609 + BNIP3@Cytosol map → map BNIP3:​RHEB@Cytosol map
  6. FKBP8@Cytosol map + rc_s2052 → map FKBP8:​RHEB|​pre@Cytosol map
  7. RHEB@Endosome Membrane map → map RHEB|​pho@Endosome Membrane map
  8. RHEB|​pho@Endosome Membrane map → map RHEB@Endosome Membrane map
As Catalyser:
  1. DEPTOR:​MLST8:​MTOR:​PRAS40*:​RPTOR@T_cell map → map (DEPTOR:​MLST8:​MTOR|​pho:​PRAS40*:​RPTOR)|​active@T_cell map
  2. DEPTOR:​MLST8:​MTOR:​PRAS40*:​RPTOR@INNATE_IMMUNE_CELL_Cytosol map → map (DEPTOR:​MLST8:​MTOR|​pho:​PRAS40*:​RPTOR)|​active@INNATE_IMMUNE_CELL_Cytosol map
  3. MLST8:​MTOR:​RPTOR@Lysosome map → map MLST8:​MTOR|​S2448_pho:​RPTOR@Lysosome map
  4. MLST8:​MTOR|​emp:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome map → map MLST8:​MTOR|​S1261_pho|​emp:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome map
  5. PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho@Membrane Lysosome map + 14-3-3*@Cytoplasm map → map 14-3-3*:​PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho@Membrane Lysosome map