Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / CELL_CELL_ADHESIONS
EMT Senescence / ADHERENS_JUNCTIONS
EMT Senescence / EMT_REGULATORS
EMT Senescence / SENESCENCE
References
PMID:25234227
Nm23-h1(NME1) binds to gelsolin and inactivates its actin-severing capacity to promote tumor cell motility and metastasis.
Dynamin 2 act on the actin cytoskeleton by Promoting membrane remodeling and endocytosis of cell receptor thanks to NDPKA (NME1) and NDPKB (NME2)
NPDK-A and dynamin associate during cytokinesis to promote chromosome stability.
Loss of NDPK-A is linked to cytokinesis failure and tetraploidy
PMID:18470881
Nm23-H1 binds Dbl-1(MCF2) and thus interferes with the ability of Dbl-1 to load GTP onto CDC42
References
em_emtc_emtc_re835( EMT Senescence ):
Cross-talk between small GTPase signaling pathways.
PMID:12134164
PMID:7673236
HRAS activates TIAM1 which is a GEF for Rac1.
RalBP1 (which is an effector for RalA and RalB) inactivates Rac1
PMID:12447393
PMID:20841469
Nm23-H1 has been shown to decrease cellular levels of active Rac1 in vivo by sequestering the Rac1 guanine nucleotide-exchange factor Tiam1
This effect of Nm23-H1 on activation of Rac1 seems to be independent of its effect on dynamin-dependent fission and does not require kinase activity
em_emtc_emtc_re838( EMT Senescence ):
PMID:11394904
PMID:10652228
GEF activity of MCF2 (DBL) towards CDC42 or Rac1 is enhanced upon TNK2 (ACK1) phosphorylation.
PMID:18470881
Nm23-H1 binds Dbl-1 and thus interferes with the ability of Dbl-1 to load GTP onto CDC42
em_re1443( EMT Senescence ):
PMID:25234227
NPDK-A and dynamin associate during cytokinesis to promote chromosome stability.
Loss of NDPK-A is linked to cytokinesis failure and tetraploidy