Protein ARF6 map

Identifiers
HUGO:ARF6

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / CELL_CELL_ADHESIONS  map
 EMT Senescence  map  / ADHERENS_JUNCTIONS  map
 EMT Senescence  map  / EMT_REGULATORS  map
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / IMMUNOSTIMULATORY_CORE_PATHWAYS  map

References
PMID:12447393
Activation of (activated) ARF6 is required for dynamin-dependent endocytosis of E-cadherin.
Nm23-H1 binds ARF6-GTP and mediates dynamin-dependent vesicle fission.
 NATURAL_KILLER  map
CASCADE:Fc_gamma_RIII
PMID:15817676
CD16 on primary human natural killer (NK) cells induces a phosphatidylinositol 3-kinase (PI3K)???dependent activation of the small G protein Arf6.
Arf6 couples CD16 to the lipid-modifying enzymes phosphatidylinositol4phosphate 5-kinase type I alpha (PI5KI??) and phospholipase D (PLD) that are involved in the control of granule secretion

Modifications:
In compartment: Cytosol
  1. ARF6@Cytosol map
Participates in complexes:
In compartment: Cytosol
  1. ARF6:​DNM2_GTP:​NME1@Cytosol map
  2. ARF6:​DNM2_GTP:​NME2@Cytosol map
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. ARF6:​GDP@INNATE_IMMUNE_CELL_Cytosol map
  2. ARF6:​GTP@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. ARF6@Cytosol map → map ARF6@Cytosol map
  2. NME1@Cytosol map → map ARF6:​DNM2_GTP:​NME1@Cytosol map
  3. em_s2267 → map ARF6:​DNM2_GTP:​NME1@Cytosol map
  4. ARF6@Cytosol map → map ARF6:​DNM2_GTP:​NME1@Cytosol map
  5. em_s2267 → map ARF6:​DNM2_GTP:​NME2@Cytosol map
  6. ARF6@Cytosol map → map ARF6:​DNM2_GTP:​NME2@Cytosol map
  7. NME2@Cytosol map → map ARF6:​DNM2_GTP:​NME2@Cytosol map
  8. ARF*@Cytosol map → map ARF6@Cytosol map
  9. ARF6:​GDP@INNATE_IMMUNE_CELL_Cytosol map + GTP@INNATE_IMMUNE_CELL_Cytosol map → map ARF6:​GTP@INNATE_IMMUNE_CELL_Cytosol map + GDP@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. Clathrin Coated pit@Cytosol map → map Clathrin dependent endosomal pathway@Clathrin coated vesicle map
  2. PLD*@INNATE_IMMUNE_CELL_Cytosol map → map PLD*@INNATE_IMMUNE_CELL_Cytosol map
  3. PIP5K1A@INNATE_IMMUNE_CELL_Cytosol map → map PIP5K1A@INNATE_IMMUNE_CELL_Cytosol map