Phenotype Cell motility map
Cell motility@Cytosol

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CYTOSKELETON_POLARITY  map
 EMT Senescence  map  / CELL_CELL_ADHESIONS  map
 EMT Senescence  map  / CELL_MATRIX_ADHESIONS  map
 EMT Senescence  map  / ECM  map
 EMT Senescence  map  / TIGHT_JUNCTIONS  map
 EMT Senescence  map  / GAP_JUNCTIONS  map
 EMT Senescence  map  / ADHERENS_JUNCTIONS  map
 EMT Senescence  map  / DESMOSOMES  map

References
Migration = motility
em_emtc_emtc_re650( EMT Senescence  map ):
PMID:22022608
Connexin43 modulates cell polarity and directional cell migration by regulating microtubule dynamics.
em_emtc_emtc_re671( EMT Senescence  map ):
GJB5 is so-called Connexin 31.1
PMID:21777377
Cx31.1 (GJB5) is predominantly expressed in the testes and the skin epidermis.
Cx31.1 rarely form functional gap junction channels, either with itself or with other Cx isoforms.
Gap junctions play important roles in various physiologic functions such as regulation of cell proliferation, cell differentiation, tissue development and cell apoptosis.
In most cases, Cxs act as tumour suppressors: Gap junctions play an important role as tumour suppressors in maintaining cell differentiation and preventing transformation
Cx31.1 reduced tumour cell proliferation, anchorage-independent growth, migration and invasion.
Moreover, development of tumours in a xenograft model was suppressed by Cx31.1, suggesting that Cx31.1 may act as a tumour suppressor in NSCLC cell lines.
em_emtc_emtc_re1306( EMT Senescence  map ):
PMID:17332325
Of the 3 AKT isofomrs, AKT2 has been shown to promote cell motility, invasiveness and metastasis
em_re1511( EMT Senescence  map ):
PMID:17967945
Cell spreading, which is characterized by the formation of filopodia and lamellipodia and represents the outward movement of cell membrane, polymerizing actin, and cytoskeletal complexes at the leading edge. Coordinated spreading and retraction allows cell migration.

Modifications:
In compartment: Cytosol
  1. Cell motility@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. AKT2@Cytosol map → map Cell motility@Cytosol map
    2. em_emtc_emtc_s3594 → map Cell motility@Cytosol map
    3. GJA1@Cytosol map → map Cell motility@Cytosol map
    4. GJB5@Cytosol map → map Cell motility@Cytosol map
    5. NISCH:​PAK1@Cytosol map → map Cell motility@Cytosol map
    6. GSN@Cytosol map → map Cell motility@Cytosol map
    7. Cytoskeleton remodeling@Nucleus map → map Cell motility@Cytosol map
    8. Cell motility@Cytosol map → map Invasiveness@Cytosol map
    9. Coordination of membrane spreading and retraction@Cytosol map → map Cell motility@Cytosol map
    10. Cell-cell adhesions@Neighbouring Cell map → map Cell motility@Cytosol map
    As Catalyser: