Reaction known_transition_omitted em_emtc_emtc_re835 map

TIAM1@Cytosol map → TIAM1@Cytosol map

Reaction regulators:
Inhibition
  1. NME1@Cytosol map
Physical_stimulation
  1. em_emtc_emtc_s3009


References
Cross-talk between small GTPase signaling pathways.
PMID:12134164
PMID:7673236
HRAS activates TIAM1 which is a GEF for Rac1.
RalBP1 (which is an effector for RalA and RalB) inactivates Rac1
PMID:12447393
PMID:20841469
Nm23-H1 has been shown to decrease cellular levels of active Rac1 in vivo by sequestering the Rac1 guanine nucleotide-exchange factor Tiam1
This effect of Nm23-H1 on activation of Rac1 seems to be independent of its effect on dynamin-dependent fission and does not require kinase activity