Phenotype Clathrin dependent endosomal pathway map
Clathrin dependent endosomal pathway@Clathrin coated vesicle

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / CYTOSKELETON_POLARITY  map

References
em_re1432( EMT Senescence  map ):
PMID:25234227
Dynamin 2 act on the actin cytoskeleton by:
- Promoting membrane remodeling and endocytosis of cell receptor thanks to NDPKA (NME1) and NDPKB (NME2)
DNM2 induces E-cadherin internalisation
em_re1453( EMT Senescence  map ):
PMID??:10402472
We conclude that a pool of surface E-cadherin is constantly trafficked through an endocytic, recycling pathway and that this may provide a mechanism for regulating the availability of E-cadherin for junction formation in development, tissue remodeling, and tumorigenesis.
em_re1454( EMT Senescence  map ):
PMID:22674073
Clathrin-mediated endocytosis appears to be responsible for two types of growth factor-induced cadherin internalization, FGF-mediated internalization of E-cadherin () and VEGF-mediated internalization of VE-cadherin.
em_re1458( EMT Senescence  map ):
Cadherin internalization can occur through either clathrin-mediated, caveolin-mediated, or macropinocytosis-like pathways. Internalized cadherin is then sorted either for lysosomal degradation or recycling back to the plasma membrane.
em_re1494( EMT Senescence  map ):
PMID:24970086
Knockdown of NM23-H1 and -H2 (fig. S1, A to E) reduced clathrin-dependent endocytosis of the transferrin (Tf) and epidermal growth factor (EGF) receptors
em_re1504( EMT Senescence  map ):
Desclozeaux and colleagues also found that cadherin recycling is necessary for maintaining adherens junctions.

Modifications:
In compartment: Clathrin coated vesicle
  1. Clathrin dependent endosomal pathway@Clathrin coated vesicle map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. Clathrin Coated pit@Cytosol map → map Clathrin dependent endosomal pathway@Clathrin coated vesicle map
    2. Clathrin dependent endosomal pathway@Clathrin coated vesicle map → map Endosomal trafficking@Endosome map
    3. Clathrin dependent endosomal pathway@Clathrin coated vesicle map → map Adherens junctions@Cytosol map
    As Catalyser:
    1. Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*:​p120*@Cytosol map → map _alpha_-Catenin*@Clathrin coated vesicle map
    2. Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*:​p120*@Cytosol map → map E-Cadherin*@Clathrin coated vesicle map
    3. Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*:​p120*@Cytosol map → map _beta_-Catenin*@Clathrin coated vesicle map
    4. Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*:​p120*@Cytosol map → map p120*@Clathrin coated vesicle map
    5. E-Cadherin*|​Y_pho@Cytosol map → map E-Cadherin*|​Y_pho@Clathrin coated vesicle map
    6. EGFR family*@Cytosol map → map EGFR family*@Clathrin coated vesicle map
    7. Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*:​p120*@Cytosol map → map degraded