Reaction state_transition rc_re69
degraded + NDUFS8@Mitochondrial inner membrane
+ MT-ND5@Mitochondrial inner membrane
+ MT-ND4@Mitochondrial inner membrane
+ MT-ND4L@Mitochondrial inner membrane
+ MT-ND3@Mitochondrial inner membrane
+ MT-ND2@Mitochondrial inner membrane
+ MT-ND1@Mitochondrial inner membrane
+ MT-ND6@Mitochondrial inner membrane
→ FMN:MT-ND1:MT-ND2:MT-ND3:MT-ND4:MT-ND4L:MT-ND5:MT-ND6:NDUFA1:NDUFA10:NDUFA11:NDUFA12:NDUFA13:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFAB1:NDUFB1:NDUFB10:NDUFB11:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFC1:NDUFC2:NDUFS1|[2Fe-2S],[4Fe-4S],[4Fe-4S]:NDUFS2:NDUFS3:NDUFS4:NDUFS5:NDUFS6:NDUFS7|[4Fe-4S]:NDUFS8|[4Fe-4S],[4Fe-4S]:NDUFV1|[4Fe-4S]:NDUFV2|[2Fe-2S]:NDUFV3@Mitochondrial inner membrane
Reaction regulators:
- Catalysis
- AIFM1:FAD@Mitochondrial inner membrane
- NDUFAF2@Mitochondrial inner membrane
- ACAD9:ECSIT:NDUFAF1@Mitochondrial inner membrane
References
PMID:16200211
NDUFAF2
PMID:17344420
ECSIT:NDUFAF1
PMID:20816094
involvement of ACAD9 in the ECSIT:NDUFAF1 complex
PMID:16218961
NDUFAF1
PMID:15526035
AIF deficient cells exhibit a decrease content of complex I. It was proposed that AIF has a role in the biogenesis or maintenance of complex I
PMID:20025615
comprehensive review about complex I