Simple molecule PAR Polymer map
PAR Polymer@Nucleus

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / PARTHANATOS  map
 Regulated Cell Death  map  / DNA_DAMAGE_RESPONSE  map

References
poly(ADP-ribose) polymer
PMID:24684389
rc_re8( Regulated Cell Death  map ):
in Ba/F3 cells, stable expression of the C-terminal cleavage product of BECN1 sensitizes cells to IL3-deprivation induced apoptosis
in vitro, incubation of isolated mitochondria with recombinant BECN1 C-terminal cleavage product triggers release of Omi/HtrA2 and cytochrome c
PMID:11832478
in vitro CASP2 unlike CASP8 induce release of CYCS , DIABLO and AIF form purified mitochondria from Hela cellsPMID: PMID:23242420
calpain-mediated Bax and Atg5 cleavage resulted in the collapse of the mitochondrial membrane potential and cytochrome c release

Modifications:
In compartment: Nucleus
  1. PAR Polymer@Nucleus map
Participates in complexes:
In compartment: Nucleus
  1. AIFM1:​PAR Polymer@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. PAR@Nucleus map → map PAR Polymer@Nucleus map
  2. AIFM1@Nucleus map + PAR Polymer@Nucleus map → map AIFM1:​PAR Polymer@Nucleus map
  3. AIFM1:​PAR Polymer@Nucleus map → map DNA~fragmentation@Nucleus map
  4. AIFM1:​PAR Polymer@Nucleus map → map Chromatin condensation@Nucleus map
  5. AIFM1:​PAR Polymer@Nucleus map → map Cell death@Cytosol map
As Catalyser:
  1. Phosphatidylserine@Cytosol map → map Phosphatidylserine@Extracellular space map
  2. Mitochondria outer~membrane integrity@Mitochondrial inner membrane map → map MOMP@Mitochondrial inner membrane map