→ MAP3K5|pho@Cytosol References
PMID:11274345
PMID:12655147
ASK1 is a MAP3K and can activate both JNK and P38 pathways.
TNF-dependent production of ROS triggers the dissociation of Trx from ASK1 and the consequently liberalised ASK1 binds to TRAF2. Finally TRAF2 appears to activate ASK1 (by phosphorylation) by enhancing and stabilising the oligomerisation of ASK1.
PMID:12556535
IGF1R signaling suppresses the ASK1-mediated stimulation of JNK/p38 thus supresses the induction of apoptosis.