Complex MLH1:PMS2 map
Complex composition:

  1. MLH1 map
  2. PMS2 map

MLH1:​PMS2@Nucleus

Identifiers
NAME:MLH1:PMS2

Maps_Modules
HMC:GENOME_INSTABILITY_AND_MUTATION
 Cell Cycle DNA Repair  map  / MMR  map
 Cell Cycle DNA Repair  map  / BER  map

References
ce_re36( Cell Cycle DNA Repair  map ):
PMID:16332722
Auto-phosphorylation of ATM in response to DNA DSB:
PMID:17303408, PMID:12556884, PMID:16858402
Amplification of ATM auto-phosphorylation by the complex ATM:MRNcomplex:H2AX:MDC1CDK5 phosphorylates and activates ATM
PMID:19151707
ce_re37( Cell Cycle DNA Repair  map ):
PMID:16332722, PMID:15136767
ATR binds stalled fork and phosphorylates CHK1 that activates checkpoint, stops cell cycle
ce_re250( Cell Cycle DNA Repair  map ):
Link between MMR and Fanconi:
PMID:17581638
ce_re260( Cell Cycle DNA Repair  map ):
DNA with O6-methylguanine adducts, MutSalpha and MutLalpha activate ATR/ATRIP and BER pathways performs the repair:
PMID:16713580, PMID:18543256
Damaged DNA triggers ATR/ATRIP complex activation
ce_re438:( Cell Cycle DNA Repair  map ) reactionType:is.a

Modifications:
Participates in complexes:
In compartment: Nucleus
  1. MLH1:​PMS2@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. MLH1:​PMS2@Nucleus map + ERCC1:​XPF*@Nucleus map → map ERCC1:​MLH1:​PMS2:​XPF*@Nucleus map
  2. FANCJ*@Nucleus map + MLH1:​PMS2@Nucleus map → map FANCJ*:​MLH1:​PMS2@Nucleus map
  3. MLH1@Nucleus map + PMS2@Nucleus map → map MLH1:​PMS2@Nucleus map
  4. MLH1:​PMS2@Nucleus map → map ce_s834
As Catalyser:
  1. ATR|​pho|​active@Nucleus map + ATRIP@Nucleus map → map ATRIP:​ATR|​pho@Nucleus map
  2. ATM@Nucleus map → map ATM|​S1981_pho|​S367_pho|​S1893_pho|​active@Nucleus map
  3. ATR@Nucleus map → map ATR|​pho|​active@Nucleus map