Phenotype Endosomal trafficking map
Endosomal trafficking@Endosome

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / CYTOSKELETON_POLARITY  map

References
Overexpression of Numb promotes sorting of Notch1 through late endosomes for degradation, whereas depletion of Numb facilitates Notch1 recycling.
em_re1441( EMT Senescence  map ):
PMID:25234227
Dynamin 2 act on the actin cytoskeleton by:
- Promoting membrane remodeling and endocytosis of cell receptor thanks to NDPKA (NME1) and NDPKB (NME2)
DNM2 induces E-cadherin internalisation

Modifications:
In compartment: Endosome
  1. Endosomal trafficking@Endosome map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. PKN1:​RhoA_B*@Cytosol map → map Endosomal trafficking@Endosome map
    2. Clathrin dependent endosomal pathway@Clathrin coated vesicle map → map Endosomal trafficking@Endosome map
    3. Caveolin mediated endocytosis@Caveolin vesicle map → map Endosomal trafficking@Endosome map
    4. Macropinocytosis@Macropinosome map → map Endosomal trafficking@Endosome map
    As Catalyser: