Protein PDGF* map

Identifiers
platelet derived growth factor subunit A
HUGO:PDGFA hgnc_id:HGNC:8799 HGNC:8799 ENTREZ:5154 UNIPROT:P04085
platelet derived growth factor subunit B
HUGO:PDGFB hgnc_id:HGNC:8800 HGNC:8800 ENTREZ:5155 UNIPROT:P01127
platelet derived growth factor C
HUGO:PDGFC hgnc_id:HGNC:8801 HGNC:8801 ENTREZ:56034 UNIPROT:Q9NRA1
HUGO:PDGFA HUGO:PDGFB HUGO:PDGFC HUGO:PDGFD

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / GROWTH_FACTORS_SIGNALING_PATHWAYS  map
 Cancer Associated Fibroblasts  map  / GROWTH_FACTORS_PRODUCTION  map

References
CASCADE:TGFB
CASCADE:PDGF
PMID:23123598
paracrine PDGF stimulation of CAFs induces production of the prototypical pro-angiogenic inducer fibroblast growth factor (FGF)-2 in both cervical carcinomas and melanoma [11] and [85].
Interestingly, CAFs activated by PDGF-CC in melanomas also secrete the extracellular matrix protein osteopontin, the action of which is known to synergistically stimulate angiogenesis together with FGF-2 and promote autocrine VEGF-A signaling in endothelial cells
PMID:15207817; PMID:19118022
PDGF receptors-mediators of autocrine tumor growth and regulators of tumor vasculature and stroma.
Tumor fibroblasts a recruted by PDGF
PMID:18232728
Inhibition of stromal PDGF receptors reduced proliferation and angiogenesis in cervical lesions through a mechanism involving suppression of expression of the angiogenic factor fibroblast growth factor 2 (FGF-2) and the epithelial cell growth factor FGF-7 by cancer-associated fibroblasts.
PMID:19111878
PDGF-C is upregulated in TAFs derived from refractory tumors and that PDGF-C, together with VEGF-A, mediates the angiogenesis induced by such TAFs in vivo. This study also demonstrates that inhibition of PDGF-C may reduce tumor angiogenesis and growth in vivo.
PMID:26921338
TGFB induces expression of PDGFB and PDGFR in CAFs and indirectly suppresses PEDF expression via PDGFB signaling
PMID:23123598 PMID:15207817 PMID:19118022

PDGF*@default

References
ca_re463( Cancer Associated Fibroblasts  map ):
PMID:??12094222??
VAV proteins activate RAC1 via induction of GDP/GTP exchange.

Modifications:
In compartment: Cytosol
  1. PDGF*@Cytosol map
In compartment: Membrane
  1. PDGF*@Membrane map
In compartment: default
  1. PDGF*@default map
Participates in complexes:
In compartment: Cytosol
  1. PDGF*:​PDGFR*@Cytosol map
In compartment: Membrane
  1. PDGF*:​PDGFR*@Membrane map
Participates in reactions:
As Reactant or Product:
  1. PDGF*@default map + PDGFR*@Cytosol map → map PDGF*:​PDGFR*@Cytosol map
  2. PDGF*@default map → map MIGRATION_INTO_THE_TUMOR@default map
  3. PDGF*@Cytosol map → map PDGF*@default map
  4. PDGF*@Cytosol map → map Angiogenesis@default map
  5. PDGF*@Cytosol map → map Angiogenesis@default map
  6. PDGF*@Cytosol map → map GROWTH_FACTORS_PRODUCTION@default map
  7. rPDGF*@Cytosol map → map PDGF*@Cytosol map
  8. PDGF*@Membrane map + PDGFR*@Membrane map → map PDGF*:​PDGFR*@Membrane map
  9. PDGF*:​PDGFR*@Membrane map → map JAK/STAT_PATHWAY@Membrane map
  10. PDGF*:​PDGFR*@Membrane map → map PLCG_PATHWAYS@Membrane map
  11. PDGF*:​PDGFR*@Membrane map → map PI3K_PATHWAY@Membrane map
  12. PDGF*:​PDGFR*@Membrane map → map MAPK_PATHWAYS@Membrane map
As Catalyser:
  1. PI3KR(p85)*@Cytosol map → map PI3KR(p85)*@Cytosol map
  2. gSPP1@Cytosol map → map rSPP1@Cytosol map
  3. gFGF7@Cytosol map → map rFGF7@Cytosol map
  4. gFGF2@Cytosol map → map rFGF2@Cytosol map
  5. ca_s94 + GTP@Cytosol map → map ca_s97 + GDP@Cytosol map
  6. gHGF@Cytosol map → map rHGF@Cytosol map
  7. gSTC1@Cytosol map → map rSTC1@Cytosol map
  8. gGPT2@Cytosol map → map rGPT2@Cytosol map
  9. FGF2@Cytosol map → map FGF2@default map