Identifiers
HUGO:PGDFRA HUGO:PGDFRB

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts   / GROWTH_FACTORS_SIGNALING_PATHWAYS 
 Cancer Associated Fibroblasts   / FIBROBLAST_ACTIVATION_MARKERS 

References
CASCADE:PDGF
CASCADE:LIF
CASCADE:TGFB
PMID:19118022
Fibroblasts expressed high amounts of osteopontin, and stimulation with PDGF-CC for 6 h increased the production even further, by 2.4-fold compared to unstimulated fibroblasts, demonstrating that the expression of osteopontin is directly regulated by signaling induced by PDGF-CC in fibroblasts
probably via PDGFR-??.
PMID:24857661
we noted an increased expression of PDGFR?? after LIF stimulation in hPDF
PMID:15229650
PDGFR alpha signaling is required for the recruitment of VEGF-producing stromal fibroblasts for tumor angiogenesis and growth
PMID:7682895; PMID:17397400
PDGF -receptor directly binds and activates PLC-gamma 1, RasGAP, P13K, and a 64 kd protein.
PI3K-Akt pathway promotes microtubule stabilization in migrating fibroblasts downstream of PDGF signaling

1. PDGFR*@Cytosol

1. PDGFR*@Membrane

1. PDGF*:​PDGFR*@Cytosol

1. PDGF*:​PDGFR*@Membrane

1. PDGF*@default + PDGFR*@Cytosol → PDGF*:​PDGFR*@Cytosol
2. rPDGFR*@Cytosol → PDGFR*@Cytosol
3. PDGFR*@Cytosol → MARKERS_OF_FIBROBLAST_ACTIVATION@default
4. PDGF*@Membrane + PDGFR*@Membrane → PDGF*:​PDGFR*@Membrane
5. PDGF*:​PDGFR*@Membrane → JAK/STAT_PATHWAY@Membrane
6. PDGF*:​PDGFR*@Membrane → PLCG_PATHWAYS@Membrane
7. PDGF*:​PDGFR*@Membrane → PI3K_PATHWAY@Membrane
8. PDGF*:​PDGFR*@Membrane → MAPK_PATHWAYS@Membrane

1. PI3KR(p85)*@Cytosol → PI3KR(p85)*@Cytosol
2. gSPP1@Cytosol → rSPP1@Cytosol
3. gFGF7@Cytosol → rFGF7@Cytosol
4. gFGF2@Cytosol → rFGF2@Cytosol
5. gSTC1@Cytosol → rSTC1@Cytosol