Protein FRAT1 map

Identifiers
frequently rearranged in advanced T-cell lymphomas
HUGO:FRAT1 HGNC:3944 ENTREZ:10023 UNIPROT:Q92837

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CELL_CELL_ADHESIONS  map
 EMT Senescence  map  / ADHERENS_JUNCTIONS  map

FRAT1@Cytosol

References
em_emtc_emtc_re466( EMT Senescence  map ):
PMID:10428961
PMID:8666229
Wnt transduces their signals through DVL1 to inhibit GSK3B, leading to the accumulation of cytosolic CTNNB1 and activation of TCF/LEF1 transcription factors.
DVL1 interacts with AXIN1 and with Frat1.
Binding of AXIN1 to DVL1 reduces formation of the destruction complex APC/AXIN1.

Modifications:
In compartment: Cytosol
  1. FRAT1@Cytosol map
Participates in complexes:
In compartment: Cytosol
  1. AXIN1:​DVL1:​FRAT1@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. AXIN1@Cytosol map + DVL1@Cytosol map + FRAT1@Cytosol map → map AXIN1:​DVL1:​FRAT1@Cytosol map
As Catalyser: