Identifiers
HUGO:RELA
RELA proto-oncogene, NF-kB subunit
HUGO:RELA hgnc_id:HGNC:9955 HGNC:9955 ENTREZ:5970 UNIPROT:Q04206
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
HUGO:RELA HGNC:9955 ENTREZ:5970 UNIPROT:Q04206
NFKB3 "nuclear factor of kappa light polypeptide gene enhancer in B-cells 3"
HUGO:RELA HGNC:9955 ENTREZ:5970 UNIPROT:Q04206 GENECARDS:RELA REACTOME:65897 KEGG:5970 ATLASONC:RELAID325 WIKI:RELA
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Adaptive Immune Response / TCR_SIGNALING
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / CORE
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / APOPTOSIS
Regulated Cell Death / STARVATION_AUTOPHAGY
Regulated Cell Death / DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death / RCD_GENES
Regulated Cell Death / TNF_RESPONSE
Regulated Cell Death / ER_STRESS
Innate Immunity / IMMUNOSTIMULATORY_CORE_PATHWAYS
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / WNT_CANONICAL
References
PMID:8383323
The interleukin 2 CD28-responsive complex contains at least three members of the NF kappa B family: c-Rel, p50, and p65.
PMID:15079071
In T cells the alternative NFkB pathway acts via RELA/p52 dimer not via RELB/p52 sownstream CD28
CD28 delivers a unique signal leading to the selective recruitment of RelA and p52 NF-??B subunits on IL-8 and Bcl-xL gene promoters
when T cells were stimulated with anti-CD3 antibody, RelA, c-Rel, and p50 were preferentially recruited to the IL-2 promoter
PMID:15536066
Signal-dependent nuclear translocation of p50 and p65 is impaired in PKC?????/??? cells.
PMID:23430059
PMID:19171876
NFkB signaling via RELA:p50 heterodimer provides
expression of proinflamatory cytokines and realisation
of M1 phenotype of macrophages.
PMID:17550372, PMID:9743347
IL13 inhibits NF??B activation via inhibition of p65 nuclear migration in inflammatory marophages
Maps_Modules
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / APOPTOSIS
Regulated Cell Death / STARVATION_AUTOPHAGY
Regulated Cell Death / DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death / RCD_GENES
Regulated Cell Death / TNF_RESPONSE
References
rc_re1372:( Regulated Cell Death ) PMID:14690596
Maps_Modules
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / APOPTOSIS
Regulated Cell Death / STARVATION_AUTOPHAGY
Regulated Cell Death / DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death / RCD_GENES
Regulated Cell Death / TNF_RESPONSE
References
rc_re1372:( Regulated Cell Death ) PMID:14690596
Maps_Modules
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / APOPTOSIS
Regulated Cell Death / STARVATION_AUTOPHAGY
Regulated Cell Death / DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death / RCD_GENES
Regulated Cell Death / TNF_RESPONSE
References
rc_re1373:( Regulated Cell Death ) PMID:14690596
→ IkB*|pho:NFKB1_p50*:RELA@T_cell
→ NFkB*@T_cell
+ RELA@T_cell + NFKB1_p50*@T_cell → IkB*:NFKB1_p50*:RELA@T_cell
→ NFKB1_p50*:RELA@T_cell + IkB*|pho@T_cell
→ NFKB2_p52*:RELA@T_cell
+ RELA@T_cell → NFKB2_p100*:RELA@T_cell
→ IkB*|pho:NFKB1_p50*:RELA@Cytosol
→ NFKB1_p50*:RELA@Cytosol + IkB*|pho@Cytosol
→ NFkB*@Cytosol
+ RELA@Cytosol + IkB*@Cytosol → IkB*:NFKB1_p50*:RELA@Cytosol
→ NFkB*@INNATE_IMMUNE_CELL_Cytosol
→ RELA@INNATE_IMMUNE_CELL_Cytosol
+ RELA@INNATE_IMMUNE_CELL_Cytosol → CBP*:RELA@INNATE_IMMUNE_CELL_Cytosol
→ IkB*|pho:NFKB1_p50*:RELA@INNATE_IMMUNE_CELL_Cytosol
→ NFKB1_p50*:RELA@INNATE_IMMUNE_CELL_Cytosol + IkB*|pho@INNATE_IMMUNE_CELL_Cytosol
→ NFKB1_p50*:RELA@INNATE_IMMUNE_CELL_Cytosol + p100@INNATE_IMMUNE_CELL_Cytosol
+ RELA@INNATE_IMMUNE_CELL_Cytosol + IkB*@INNATE_IMMUNE_CELL_Cytosol → IkB*:NFKB1_p50*:RELA@INNATE_IMMUNE_CELL_Cytosol
+ RELA@Cytosol → NFKB1_p50*:RELA@Cytosol
+ NFKB1_p50*:RELA@Cytosol → rc_s5553
→ RELA|T254_pho|prolyl isomerized@Cytosol
→ RELA|T254_pho|ubi@Cytosol
→ degraded
→ RELA|T254_pho@Cytosol
→ RELA@Cytosol
→ RELA|T254_pho@Cytosol
→ NFKB1_p50*:RELA@Nucleus
→ NFKB1@Nucleus
→ Survival@Cytosol
→ Autophagy survival@Cytosol
→ Apoptotic death@Cytosol
→ NFKB*@Cytosol
→ NFKB1_p50*:RELA@Nucleus
+ NFKB1_p50*:RELA@Nucleus → su_wca1_s_wca3_s281