Identifiers
NAME:IkB*:NFKB1_p50*:RELA
Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / CORE
References
PMID:20138012
NF-??B heterodimer (RelA-p50) translocates to the nucleus, where it activates the transcription of its target genes ( Karin and Ben-Neriah, 2000 and Pereira and Oakley, 2008). Nuclear p65 staining was detected in the stroma of HPV skin sections but not in the skin of nontransgenic control mice
ca_re232( Cancer Associated Fibroblasts ):
PMID:15145317
The activated IKK complex,
predominantly acting through IKKb in an IKKg-dependent
manner, catalyzes the phosphorylation of IkBs (at sites
equivalent to Ser32 and Ser36 of IkBa), polyubiquitination
(at sites equivalent to Lys21 and Lys22 of IkBa) and
subsequent degradation by the 26S proteasome. The
released NF-kB dimers (in this pathway, most commonly
the p50??? RelA dimer) translocate to the nucleus, bind DNA
and activate gene transcription.
PMID:17485448
IL10 Iinhibits IKBa??? ???phosphorylation and proteasomal degradation and prevents activation of downstream??? ???NFkB??? ???signaling.
PMID:14660645, PMID:18264787, PMID:11460167
Activated TAK1 phosphorylates IKK-beta proteins
leading to activation of NF-??B downstream of HMGB1..
ca_re233( Cancer Associated Fibroblasts ):
catalyzes the phosphorylation of IkBs (at sites
Identifiers
NAME:IkB*:NFKB1_p50*:RELA
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Innate Immunity / IMMUNOSTIMULATORY_CORE_PATHWAYS
References
in_re877( Innate Immunity ):
PMID:15145317
The activated IKK complex,
predominantly acting through IKKb in an IKKg-dependent
manner, catalyzes the phosphorylation of IkBs (at sites
equivalent to Ser32 and Ser36 of IkBa), polyubiquitination
(at sites equivalent to Lys21 and Lys22 of IkBa) and
subsequent degradation by the 26S proteasome. The
released NF-kB dimers (in this pathway, most commonly
the p50??? RelA dimer) translocate to the nucleus, bind DNA
and activate gene transcription.
PMID:17485448
IL10 Iinhibits IKBa??? ???phosphorylation and proteasomal degradation and prevents activation of downstream??? ???NFkB??? ???signaling.
PMID:14660645, PMID:18264787, PMID:11460167
Activated TAK1 phosphorylates IKK-beta proteins
leading to activation of NF-??B downstream of HMGB1..
in_re878( Innate Immunity ):
catalyzes the phosphorylation of IkBs (at sites
Identifiers
NAME:IkB*:NFKB1_p50*:RELA
Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / CORE
References
PMID:20138012
NF-??B heterodimer (RelA-p50) translocates to the nucleus, where it activates the transcription of its target genes ( Karin and Ben-Neriah, 2000 and Pereira and Oakley, 2008). Nuclear p65 staining was detected in the stroma of HPV skin sections but not in the skin of nontransgenic control mice
ca_re232( Cancer Associated Fibroblasts ):
PMID:15145317
The activated IKK complex,
predominantly acting through IKKb in an IKKg-dependent
manner, catalyzes the phosphorylation of IkBs (at sites
equivalent to Ser32 and Ser36 of IkBa), polyubiquitination
(at sites equivalent to Lys21 and Lys22 of IkBa) and
subsequent degradation by the 26S proteasome. The
released NF-kB dimers (in this pathway, most commonly
the p50??? RelA dimer) translocate to the nucleus, bind DNA
and activate gene transcription.
PMID:17485448
IL10 Iinhibits IKBa??? ???phosphorylation and proteasomal degradation and prevents activation of downstream??? ???NFkB??? ???signaling.
PMID:14660645, PMID:18264787, PMID:11460167
Activated TAK1 phosphorylates IKK-beta proteins
leading to activation of NF-??B downstream of HMGB1..
Identifiers
NAME:IkB*:NFKB1_p50*:RELA
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Innate Immunity / IMMUNOSTIMULATORY_CORE_PATHWAYS
References
in_re877( Innate Immunity ):
PMID:15145317
The activated IKK complex,
predominantly acting through IKKb in an IKKg-dependent
manner, catalyzes the phosphorylation of IkBs (at sites
equivalent to Ser32 and Ser36 of IkBa), polyubiquitination
(at sites equivalent to Lys21 and Lys22 of IkBa) and
subsequent degradation by the 26S proteasome. The
released NF-kB dimers (in this pathway, most commonly
the p50??? RelA dimer) translocate to the nucleus, bind DNA
and activate gene transcription.
PMID:17485448
IL10 Iinhibits IKBa??? ???phosphorylation and proteasomal degradation and prevents activation of downstream??? ???NFkB??? ???signaling.
PMID:14660645, PMID:18264787, PMID:11460167
Activated TAK1 phosphorylates IKK-beta proteins
leading to activation of NF-??B downstream of HMGB1..
Identifiers
NAME:IkB*:NFKB1_p50*:RELA
References
ad_re397( Adaptive Immune Response ):
PMID:15145317
The activated IKK complex,
predominantly acting through IKKb in an IKKg-dependent
manner, catalyzes the phosphorylation of IkBs (at sites
equivalent to Ser32 and Ser36 of IkBa), polyubiquitination
(at sites equivalent to Lys21 and Lys22 of IkBa) and
subsequent degradation by the 26S proteasome. The
released NF-kB dimers (in this pathway, most commonly
the p50??? RelA dimer) translocate to the nucleus, bind DNA
and activate gene transcription.
PMID:17485448
IL10 Iinhibits IKBa??? ???phosphorylation and proteasomal degradation and prevents activation of downstream??? ???NFkB??? ???signaling.
PMID:14660645, PMID:18264787, PMID:11460167
Activated TAK1 phosphorylates IKK-beta proteins
leading to activation of NF-??B downstream of HMGB1..
Identifiers
NAME:IkB*:NFKB1_p50*:RELA
References
ad_re397( Adaptive Immune Response ):
PMID:15145317
The activated IKK complex,
predominantly acting through IKKb in an IKKg-dependent
manner, catalyzes the phosphorylation of IkBs (at sites
equivalent to Ser32 and Ser36 of IkBa), polyubiquitination
(at sites equivalent to Lys21 and Lys22 of IkBa) and
subsequent degradation by the 26S proteasome. The
released NF-kB dimers (in this pathway, most commonly
the p50??? RelA dimer) translocate to the nucleus, bind DNA
and activate gene transcription.
PMID:17485448
IL10 Iinhibits IKBa??? ???phosphorylation and proteasomal degradation and prevents activation of downstream??? ???NFkB??? ???signaling.
PMID:14660645, PMID:18264787, PMID:11460167
Activated TAK1 phosphorylates IKK-beta proteins
leading to activation of NF-??B downstream of HMGB1..
→ IkB*|pho:NFKB1_p50*:RELA@T_cell
+ RELA@T_cell + NFKB1_p50*@T_cell → IkB*:NFKB1_p50*:RELA@T_cell
→ NFKB1_p50*:RELA@T_cell + IkB*|pho@T_cell
→ IkB*|pho:NFKB1_p50*:RELA@Cytosol
→ NFKB1_p50*:RELA@Cytosol + IkB*|pho@Cytosol
+ RELA@Cytosol + IkB*@Cytosol → IkB*:NFKB1_p50*:RELA@Cytosol
→ IkB*|pho:NFKB1_p50*:RELA@INNATE_IMMUNE_CELL_Cytosol
→ NFKB1_p50*:RELA@INNATE_IMMUNE_CELL_Cytosol + IkB*|pho@INNATE_IMMUNE_CELL_Cytosol
+ RELA@INNATE_IMMUNE_CELL_Cytosol + IkB*@INNATE_IMMUNE_CELL_Cytosol → IkB*:NFKB1_p50*:RELA@INNATE_IMMUNE_CELL_Cytosol