Identifiers
HUGO:NFKB1
MODULE:CAF
MODULE:CORE
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
HUGO:NFKB1 HGNC:7794 ENTREZ:4790 UNIPROT:P19838
MODULE:CORE_SIGNALING_PATHWAYS
MODULE:IMMUNOSTIMULATORY_CORE_PATHWAYS
HUGO:NFKB1 HGNC:7794 ENTREZ:4790 UNIPROT:P19838 GENECARDS:NFKB1 REACTOME:57855 KEGG:4790 ATLASONC:NFKB1ID323 WIKI:NFKB1
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Adaptive Immune Response / TCR_SIGNALING
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / APOPTOSIS
Regulated Cell Death / STARVATION_AUTOPHAGY
Regulated Cell Death / DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death / RCD_GENES
Regulated Cell Death / TNF_RESPONSE
Regulated Cell Death / ER_STRESS
Innate Immunity / IMMUNOSTIMULATORY_CORE_PATHWAYS
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / WNT_CANONICAL
References
PMID:8383323
The interleukin 2 CD28-responsive complex contains at least three members of the NF kappa B family: c-Rel, p50, and p65
PMID:15079071
when T cells were stimulated with anti-CD3 antibody, RelA, c-Rel, and p50 were preferentially recruited to the IL-2 promoter
PMID:14668329
predominance of p50-p50 homodimers binding to the IL-2 promoter ??B site in tolerant T cells CD4+ correlated with repression of NF??B-driven transcription.
PMID:8580069
PMID:15536066
Signal-dependent nuclear translocation of p50 and p65 is impaired in PKC?????/??? cells.
PMID:20138012
NF-??B heterodimer (RelA-p50) translocates to the nucleus, where it activates the transcription of its target genes ( Karin and Ben-Neriah, 2000 and Pereira and Oakley, 2008). Nuclear p65 staining was detected in the stroma of HPV skin sections but not in the skin of nontransgenic control mice
PMID:23430059
PMID:19171876, PMID:17145890
NFkB p50/p50 homodimers (which lack the transactivation
domain) compete with canonical p65/p50 heterodimers for
the binding sites on the inflammatory
gene promoters, thereby blocking p65/p50 promoter
binding and gene transcription.
p50 NF-kappaB overexpression accounts for the
inability of tumor assasiated macrophages to mount
an effective M1 antitumor response capable of inhibiting tumor growth.
PMID:17404308
CSF1 downregulates TNF, IL-23p19, IL-12p40 expression probably via induction of acomulation of p50 homodimer and inhibition of p65/p50 NF-kB signaling.
References
ad_re411( Adaptive Immune Response ):
PMID:17404308
CSF1 induces acomulation of p50 homodimer and inhibition of p65/p50 NF-kB signaling
References
ad_re411( Adaptive Immune Response ):
PMID:17404308
CSF1 induces acomulation of p50 homodimer and inhibition of p65/p50 NF-kB signaling
References
in_re867( Innate Immunity ):
PMID:17404308
CSF1 induces acomulation of p50 homodimer and inhibition of p65/p50 NF-kB signaling
in_re558( Innate Immunity ):
PMID:17485448
Inhibition of??? ???NFkB signaling downstream of??? ???ABIN3??? ???
inhibits expression of??? ???IL8,??? ???IL6,??? ???TNF,??? ???IL12
PMID:16413922
NFKBID (IkBNS) inhibit late phase (after 3h) of expression of proinflanotory cytokines
Il-12p40 (IL-12p40), Il-18 (IL-18) and Csf3 (G_CSF).
PMID:16243976
IRF4 downregulates expression of TNFa, IL12p40, IL6 probably via inhibition of NF-kB and JNK signaling pathways.
CSF1 downregulates TNF, IL-23p19, IL-12p40 expression probably via induction of acomulation of p50 homodimer and inhibition of p65/p50 NF-kB signaling.
CSF2 upregulates expression of TNF, and have positive influence on IL12p70 (p40+p35), IL23 (p40+p19) expression, probably via induction rapid IkBa degradetion, RELA nuclear translocation and formation p65/p50 heterodimers provided induction of NFkB signaling.
PMID:23390297
MIF inhitits expression of M1 markers such as IL12p40
in_re1031( Innate Immunity ):
PMID:12907458
Bcl-3??? ???interacted with NF-??B p50,
both Bcl-3??? ???and p50??? ???were recruited to the TNF promoter,
BCL3??? ??? and??? ???p50??? ???NFkB recruitment to??? ???TNF ???promoter
prevents binding of??? ???p65/p50??? ???NFkB??? ???heterodimers
to??? ???TNF promotor and suppresses??? ???TNF ???expression
downstream of??? ???IL10.
PMID:15465827
BCL3 forms complex with HDAC1 and
repression of the TNF promoter by BCL3
requires Histone Deacetylase Activity.
BCL3 inhibits expression of TNF.
PMID:11875494
HMOX1 (HO1) mediates IL-10-induced suppression of TNF production.
PMID:16878026, PMID:14660645, PMID:15644117, PMID:10952726
Increased TNF expression downstream of HMGB1 is regulated via MYD88 and probably NFkB.
PMID:10754326
Human TNF-alpha gene has binding sites for NF-kappa B. By transient transfection,
NF-kappa B p65 and p50 synergistically activated the TNF-alpha promoter.
Although both the kappa B1 and kappa B3 sites bound transcriptionally active NF-kappa B p50/p65 heterodimers, only the kappa B1 site contributed to down-regulation by NF-kappa B p50 homodimers.
PMID:7594497
TGFB1 and IL10 dowregulate expression of TNF.
MIF inhitits expression of M1 markers such as TNF.
References
in_re867( Innate Immunity ):
PMID:17404308
CSF1 induces acomulation of p50 homodimer and inhibition of p65/p50 NF-kB signaling
in_re1092( Innate Immunity ):
PMID:12907458, PMID:12907458
STAT3??? ??? directly??? ???up-regulates??? ???BCL3??? ???expression
downstream of??? ???IL10.
PMID:15465827
NFkB p50 is needfull for BCL3 expression.
→ IkB*|pho:NFKB1_p50*:RELA@T_cell
→ IkB*|pho:NFKB1_p50*:RELB@T_cell
→ IkB*|pho:NFKB1_p50*:cREL*@T_cell
→ NFkB*@T_cell
→ NFkB*@T_cell
→ NFKB1_p50*|hm2@T_cell
→ NFKB1_p50*@T_cell
+ cREL*@T_cell + NFKB1_p50*@T_cell → IkB*:NFKB1_p50*:cREL*@T_cell
+ RELB@T_cell + NFKB1_p50*@T_cell → IkB*:NFKB1_p50*:RELB@T_cell
+ RELA@T_cell + NFKB1_p50*@T_cell → IkB*:NFKB1_p50*:RELA@T_cell
→ NFKB1_p50*:cREL*@T_cell + IkB*|pho@T_cell
→ NFKB1_p50*:RELB@T_cell + IkB*|pho@T_cell
→ NFKB1_p50*:RELA@T_cell + IkB*|pho@T_cell
+ BCL3@T_cell → BCL3:NFKB1_p50*|hm2@T_cell
→ IkB*|pho:NFKB1_p50*:RELA@Cytosol
→ NFKB1_p50*:RELA@Cytosol + IkB*|pho@Cytosol
→ IkB*|pho:NFKB1_p50*:RELB@Cytosol
→ NFKB1_p50*:RELB@Cytosol + IkB*|pho@Cytosol
→ NFkB*@Cytosol
→ NFkB*@Cytosol
+ RELB@Cytosol + IkB*@Cytosol → IkB*:NFKB1_p50*:RELB@Cytosol
+ RELA@Cytosol + IkB*@Cytosol → IkB*:NFKB1_p50*:RELA@Cytosol
+ NFKB1_p50*@INNATE_IMMUNE_CELL_Cytosol → BCL3:NFKB1_p50*@INNATE_IMMUNE_CELL_Cytosol
→ NFkB*@INNATE_IMMUNE_CELL_Cytosol
→ NFkB*@INNATE_IMMUNE_CELL_Cytosol
→ NFkB*@INNATE_IMMUNE_CELL_Cytosol
→ NFKB1_p50*|hm2@INNATE_IMMUNE_CELL_Cytosol
→ IkB*|pho:NFKB1_p50*:RELA@INNATE_IMMUNE_CELL_Cytosol
→ NFKB1_p50*:RELA@INNATE_IMMUNE_CELL_Cytosol + IkB*|pho@INNATE_IMMUNE_CELL_Cytosol
→ IkB*|pho:NFKB1_p50*:RELB@INNATE_IMMUNE_CELL_Cytosol
→ IkB*|pho:NFKB1_p50*:cREL*@INNATE_IMMUNE_CELL_Cytosol
→ NFKB1_p50*:RELB@INNATE_IMMUNE_CELL_Cytosol + IkB*|pho@INNATE_IMMUNE_CELL_Cytosol
→ NFKB1_p50*:cREL*@INNATE_IMMUNE_CELL_Cytosol + IkB*|pho@INNATE_IMMUNE_CELL_Cytosol
→ NFKB1_p50*:RELA@INNATE_IMMUNE_CELL_Cytosol + p100@INNATE_IMMUNE_CELL_Cytosol
→ NFKB1_p50*:cREL*@INNATE_IMMUNE_CELL_Cytosol + p100@INNATE_IMMUNE_CELL_Cytosol
+ RELA@INNATE_IMMUNE_CELL_Cytosol + IkB*@INNATE_IMMUNE_CELL_Cytosol → IkB*:NFKB1_p50*:RELA@INNATE_IMMUNE_CELL_Cytosol
+ RELB@INNATE_IMMUNE_CELL_Cytosol + IkB*@INNATE_IMMUNE_CELL_Cytosol → IkB*:NFKB1_p50*:RELB@INNATE_IMMUNE_CELL_Cytosol
+ cREL*@INNATE_IMMUNE_CELL_Cytosol + IkB*@INNATE_IMMUNE_CELL_Cytosol → IkB*:NFKB1_p50*:cREL*@INNATE_IMMUNE_CELL_Cytosol
+ NFKB1_p50*@INNATE_IMMUNE_CELL_Cytosol → NFKB1_p50*:NFKBID@INNATE_IMMUNE_CELL_Cytosol
→ NFKB1_p50*@INNATE_IMMUNE_CELL_Cytosol
→ NFKB1_p50*@Cytosol
+ RELA@Cytosol → NFKB1_p50*:RELA@Cytosol
+ NFKB1_p50*:RELA@Cytosol → rc_s5553
→ NFKB1_p50*:RELA@Nucleus
→ NFKB1@Nucleus
→ Survival@Cytosol
→ Autophagy survival@Cytosol
→ Apoptotic death@Cytosol
→ NFKB*@Cytosol
→ NFKB1_p50*:RELA@Nucleus
+ NFKB1_p50*:RELA@Nucleus → su_wca1_s_wca3_s281
→ NFkB*@T_cell
→ rIL2@T_cell
→ rIL2RA@T_cell
→ rIFNG@T_cell
→ rTNF@INNATE_IMMUNE_CELL_Cytosol
→ rBCL3@INNATE_IMMUNE_CELL_Cytosol
→ rIL12p40*@INNATE_IMMUNE_CELL_Cytosol
→ rIL23A@INNATE_IMMUNE_CELL_Cytosol
→ rNOS2@Nucleus