Phenotype PARP1 overactivation map
PARP1 overactivation@Nucleus

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / PARTHANATOS  map
 Regulated Cell Death  map  / DNA_DAMAGE_RESPONSE  map

References
PMID:23110147
PMID:17116881
PARP1 one is able to trigger necroptosis, autophagy or apoptosis depending of cell type and state
PMID:24684389
PMID:27048819
rc_re1577( Regulated Cell Death  map ):
PMID:27646922
Excess cellular levels of ROS cause damage to proteins, nucleic acids, lipids, membranes and organelles, which can lead to activation of cell death processes such as apoptosis.

Modifications:
In compartment: Nucleus
  1. PARP1 overactivation@Nucleus map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. ROS Production@Cytosol map → map PARP1 overactivation@Nucleus map
    2. PARP activation@Cytosol map → map PARP1 overactivation@Nucleus map
    3. DNA alkylating agents@Nucleus map → map PARP1 overactivation@Nucleus map
    4. DNA~damage@Nucleus map → map PARP1 overactivation@Nucleus map
    5. PARP1 overactivation@Nucleus map → map NAD and ATP depletion@Nucleus map
    6. PARP1 overactivation@Nucleus map → map Autophagy survival@Cytosol map
    7. ROS@Nucleus map → map PARP1 overactivation@Nucleus map
    8. PJ34@Nucleus map → map PARP1 overactivation@Nucleus map
    9. DPQ@Nucleus map → map PARP1 overactivation@Nucleus map
    10. 3-AB@Nucleus map → map PARP1 overactivation@Nucleus map
    As Catalyser:
    1. ce_s2572 → map ce_s2572
    2. PAR@Nucleus map → map PAR@Cytosol map
    3. PAR@Nucleus map → map PAR Polymer@Nucleus map