Complex BBC3:BCL2-XL* map
Complex composition:

  1. BBC3 map
  2. BCL2-XL* map

BBC3:​BCL2-XL*@Mitochondria

Identifiers
NAME:BBC3:BCL2-XL*

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map

References
PMID:11463392
BBC3 (so-called PUMA, p53 upregulated modulator of apoptosis) as a target for activation by p53.
This gene encodes two BH3 domain???containing proteins that are induced in cells following p53 activation.
BBC3 binds to BCL2, localize to the mitochondria to induce cytochrome c release, and activate the rapid induction of programmed cell death.
Antisense inhibition of PUMA expression reduced the apoptotic response to p53, and PUMA is likely to play a role inmediating p53-induced cell death through the cytochrome c/Apaf-1???dependent pathway.
PMID:11463391
PUMA was found to be exclusively mitochondrial and to bind to BCL2 and BCL2L1 through a BH3 domain.
It is via this binding to BBC3 (an apoptic inducer) that BCL2L1 exhibits its anti-apoptic effect.

BBC3:​BCL2-XL*@Mitochondrial inner membrane

Identifiers
NAME:BBC3:BCL2-XL*

References
rc_re593:( Regulated Cell Death  map ) PMID:16608847

Modifications:
Participates in complexes:
In compartment: Mitochondria
  1. BBC3:​BCL2-XL*@Mitochondria map
In compartment: Mitochondrial inner membrane
  1. BBC3:​BCL2-XL*@Mitochondrial inner membrane map
Participates in reactions:
As Reactant or Product:
  1. BBC3@Mitochondria map + BCL2-XL*@Mitochondria map → map BBC3:​BCL2-XL*@Mitochondria map
  2. BBC3@Mitochondrial inner membrane map + BCL2-XL*@Mitochondrial inner membrane map → map BBC3:​BCL2-XL*@Mitochondrial inner membrane map
As Catalyser: