Protein NEDD4 map

Identifiers
neural precursor cell expressed, developmentally sown regulated 4
HUGO:NEDD4, HGNC:7727, ENTREZ:4734, UNIPROT:P46934
neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
neural precursor cell expressed developmentally down-regulated 4
HUGO:NEDD4 HGNC:7727 ENTREZ:4734 UNIPROT:P46934 GENECARDS:NEDD4 REACTOME:60051 KEGG:4734 ATLASONC:GC_NEDD4 WIKI:NEDD4

Maps_Modules
HMC:GENOME_INSTABILITY_AND_MUTATION
 Cell Cycle DNA Repair  map  / BER  map
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / DEPENDANCE_RECEPTORS  map
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / PI3K_AKT_MTOR  map

References
PMID:17996703
PMID:22679284
Ptc allows the activation of caspase-9 via its ubiquitination, which occurs via the recruitment by Ptc of NEDD4.
PMID:19652529
PMID:17218261
PMID:17218260
PMID:18562292
ANNOTATION:this article describes that NEDD4-1 is not required for PTEN stability and

NEDD4@Nucleus

References
ce_re481:( Cell Cycle DNA Repair  map ) PMID:17996703

NEDD4@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / DEPENDANCE_RECEPTORS  map

References
rc_re1702( Regulated Cell Death  map ):
PMID:19465923
in the absence of Shh, Ptc recruits a protein complex that includes DRAL, one of the caspase recruitment (CARD)-domain containing proteins TUCAN (family member, 8) or NALP1 (NLR family, pyrin domain containing 1) and apical caspase-9

NEDD4@Cytoplasm

References
s_akt1_re14( Survival  map ):
PMID:17218261
PMID:17218260

Modifications:
In compartment: Cytoplasm
  1. NEDD4@Cytoplasm map
In compartment: Cytosol
  1. NEDD4@Cytosol map
In compartment: Nucleus
  1. NEDD4@Nucleus map
Participates in complexes:
In compartment: Cytosol
  1. DRAL*:​NEDD4:​NLRP1:​TUCAN*@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. PTCH*@Cytosol map + DRAL*@Cytosol map + TUCAN*@Cytosol map + NLRP1@Cytosol map + NEDD4@Cytosol map → map DRAL*:​NEDD4:​NLRP1:​TUCAN*@Cytosol map
As Catalyser:
  1. Transcription machine_br_(RNAPII)*@Nucleus map → map Transcription machine_br_(RNAPII)*|​ubi@Nucleus map
  2. Caspase9*@Cytosol map → map Caspase9*|​K63_ubi@Cytosol map
  3. PTEN@Cytoplasm map → map PTEN|​K13_ubi@Cytoplasm map
  4. PTEN@Cytoplasm map → map PTEN|​K289_ubi|​K13_ubi@Cytoplasm map
  5. PTEN@Cytoplasm map → map PTEN|​K289_ubi@Cytoplasm map