Protein KSR1 map

Identifiers
kinase suppressor of ras 1
"kinase suppressor of ras" KSR
HUGO:KSR1 HGNC:6465 ENTREZ:8844 UNIPROT:Q8IVT5

Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / MAPK  map

References
KSR1 is a scaffold protein for ERK cascade. It normally localises in the cytosol but after GF treatment it moves to the plasma membrane. Its interaction with MEK1/2 is constitutive. Under endogenous conditions KSR1 facilitates the association of MEK and B-Raf (and not C-Raf) thus promoting MEK and ERK activation (on plasma membrane).
PMID:19541618

Modifications:
Participates in complexes:
In compartment: Cytoplasm
  1. KSR1:​MEK*@Cytoplasm map
  2. IMP*:​KSR1:​MEK*@Cytoplasm map
  3. ERK*|​pho|​pho:​KSR1:​MEK*|​pho|​pho@Cytoplasm map
  4. ERK*|​pho|​pho|​hm2:​KSR1:​MEK*|​pho|​pho@Cytoplasm map
In compartment: Plasma Membrane
  1. BRAF|​pho:​GRB2:​KSR1:​MEK*|​pho|​pho:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map
  2. BRAF|​pho:​ERK*|​pho|​pho:​GRB2:​KSR1:​MEK*|​pho|​pho:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map
Participates in reactions:
As Reactant or Product:
  1. BRAF|​pho:​GRB2:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map + KSR1:​MEK*@Cytoplasm map → map BRAF|​pho:​GRB2:​KSR1:​MEK*|​pho|​pho:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map
  2. BRAF|​pho:​GRB2:​KSR1:​MEK*|​pho|​pho:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map + ERK*@Cytoplasm map → map BRAF|​pho:​ERK*|​pho|​pho:​GRB2:​KSR1:​MEK*|​pho|​pho:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map
  3. ERK*|​pho|​pho:​KSR1:​MEK*|​pho|​pho@Cytoplasm map → map KSR1:​MEK*@Cytoplasm map + ERK*@Cytoplasm map
  4. BRAF|​pho:​ERK*|​pho|​pho:​GRB2:​KSR1:​MEK*|​pho|​pho:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map → map KSR1:​MEK*@Cytoplasm map + BRAF|​pho:​GRB2:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map + ERK*|​pho|​pho@Cytoplasm map
  5. BRAF|​pho:​GRB2:​KSR1:​MEK*|​pho|​pho:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map → map BRAF|​pho:​GRB2:​KSR1-NTER*:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map + KSR1-CTER*:​MEK*@Cytoplasm map
  6. IMP*:​KSR1:​MEK*@Cytoplasm map → map IMP*@Cytoplasm map + KSR1:​MEK*@Cytoplasm map
  7. BRAF|​pho:​ERK*|​pho|​pho:​GRB2:​KSR1:​MEK*|​pho|​pho:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map → map ERK*|​pho|​pho:​KSR1:​MEK*|​pho|​pho@Cytoplasm map + BRAF|​pho:​GRB2:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map
  8. ERK*|​pho|​pho:​KSR1:​MEK*|​pho|​pho@Cytoplasm map + ERK*|​pho|​pho@Cytoplasm map → map ERK*|​pho|​pho|​hm2:​KSR1:​MEK*|​pho|​pho@Cytoplasm map
As Catalyser:
  1. PLA2G4A@Cytoplasm map → map PLA2G4A|​pho@Cytoplasm map