Protein HMGA2 map

Identifiers
high mobility group AT-hook 2
HUGO:HMGA2 HGNC:5009 ENTREZ:8091 UNIPROT:P52926

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map

References
PMID:16831886
PMID:18832382
HMGA2 directly binds to the SNAIL1 promoter and acts as a transcriptional regulator of SNAIL1 expression.
HMGA2 cooperates with SMAD3 and SMAD4 to execute a dramatic super-induction of the SNAIL1 promoter.
Same results were obtained with SNAI2, ZEB1, ZEB2 and TWIST1
HMGA2 cooperates with TGFB1 signaling to represse ID2 transcriptomal expression

Modifications:
In compartment: Nucleus
  1. HMGA2@Nucleus map
Participates in complexes:
In compartment: Nucleus
  1. HMGA2:​SMAD2_3*:​SMAD4@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. SMAD2_3*:​SMAD4@Nucleus map + HMGA2@Nucleus map → map HMGA2:​SMAD2_3*:​SMAD4@Nucleus map
As Catalyser:
  1. gSNAI1@Nucleus map → map rSNAI1@Nucleus map
  2. gID1@Nucleus map → map rID1@Nucleus map
  3. gSNAI2@Nucleus map → map rSNAI2@Nucleus map
  4. gZEB1@Nucleus map → map rZEB1@Nucleus map
  5. gZEB2@Nucleus map → map rZEB2@Nucleus map
  6. gTWIST1@Nucleus map → map rTWIST1@Nucleus map