RNA ZEB2 map

Identifiers
zinc finger E-box binding homeobox 2
HUGO:ZEB2, HGNC:14881, ENTREZ:9839, GENECARDS:GC02M145145

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map

References
PMID:19839049
Feedback loops
PMID:225147423

rZEB2@Nucleus

References
em_emtc_emtc_re5( EMT Senescence  map ):
PMID:16831886
PMID:18832382
HMGA2 directly binds to the SNAIL1 promoter and acts as a transcriptional regulator of SNAIL1 expression.
HMGA2 cooperates with SMAD3 and SMAD4 to execute a dramatic super-induction of the SNAIL1 promoter.
Same results were obtained with SNAI2, ZEB1, ZEB2 and TWIST1
HMGA2 cooperates with TGFB1 signaling to represse ID2 transcriptomal expression
em_emtc_emtc_re1151( EMT Senescence  map ):
PMID:22753312
A direct link between ZEB2 and miRNA-192 in the diabetic kidney.
miRNA-192 expression is regulated by both the p53 and TGFb pathways
em_emtc_emtc_re1161( EMT Senescence  map ):
direct regulation of ZEB2 by miR-30e

Modifications:
In compartment: Nucleus
  1. rZEB2@Nucleus map
Participates in complexes:
In compartment: Cytosol
  1. MIR192:​ZEB2@Cytosol map
  2. MIR30E:​ZEB2@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. r_beta_-Catenin*_ZEB1_ZEB2*@Nucleus map → map rZEB2@Nucleus map
  2. rBMI1_BIRC5_KLF4_SOX2_SNAI1_ZEB2*@Nucleus map → map rZEB2@Nucleus map
  3. rZEB1_ZEB2*@Nucleus map → map rZEB2@Nucleus map
  4. rZEB2@Nucleus map + arMIR192@Nucleus map → map MIR192:​ZEB2@Cytosol map
  5. arMIR30E@Nucleus map + rZEB2@Nucleus map → map MIR30E:​ZEB2@Cytosol map
  6. rPRKCE_ZEB1_ZEB2*@Nucleus map → map rZEB2@Nucleus map
  7. rZEB2@Nucleus map → map ZEB2@Nucleus map
  8. gZEB2@Nucleus map → map rZEB2@Nucleus map
As Catalyser: