Identifiers
zinc finger E-box binding homeobox 2
HUGO:ZEB2, HGNC:14881, ENTREZ:9839, GENECARDS:GC02M145145
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
References
PMID:19839049
Feedback loops
PMID:225147423
References
em_emtc_emtc_re5( EMT Senescence ):
PMID:16831886
PMID:18832382
HMGA2 directly binds to the SNAIL1 promoter and acts as a transcriptional regulator of SNAIL1 expression.
HMGA2 cooperates with SMAD3 and SMAD4 to execute a dramatic super-induction of the SNAIL1 promoter.
Same results were obtained with SNAI2, ZEB1, ZEB2 and TWIST1
HMGA2 cooperates with TGFB1 signaling to represse ID2 transcriptomal expression