Reaction transcription em_emtc_emtc_re5 map

gZEB2@Nucleus map → rZEB2@Nucleus map

Reaction regulators:
Physical_stimulation
  1. SMAD2_3*:​SMAD4@Nucleus map
  2. HMGA2:​SMAD2_3*:​SMAD4@Nucleus map


References
PMID:16831886
PMID:18832382
HMGA2 directly binds to the SNAIL1 promoter and acts as a transcriptional regulator of SNAIL1 expression.
HMGA2 cooperates with SMAD3 and SMAD4 to execute a dramatic super-induction of the SNAIL1 promoter.
Same results were obtained with SNAI2, ZEB1, ZEB2 and TWIST1
HMGA2 cooperates with TGFB1 signaling to represse ID2 transcriptomal expression