Identifiers
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
HUGO:ATP5B HGNC:830 ENTREZ:506 UNIPROT:P06576
Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
Regulated Cell Death / MITOCHONDRIAL_GENES
Regulated Cell Death / MITOCHONDRIAL_METABOLISM
Regulated Cell Death / OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE
RECON2
Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
Regulated Cell Death / MITOCHONDRIAL_GENES
Regulated Cell Death / MITOCHONDRIAL_METABOLISM
Regulated Cell Death / OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE
References
rc_re979( Regulated Cell Death ):
PMID:11410595
ATPAF1 role in assembly of mitochondrial ATP synthase inferred from yeast, on the basis that ATPAF1 interacts with ATP5B (Y2H) and complements the yeast mutant
similar function suggested for ATPAF2
PMID:14701807
in vitro, human ATPAF2 functions as a protein chaperone
PMID:14757859
a mutation found in gene ATPAF2 from a patient with mitochondrial encephalomyopathies supports the role of ATPAF2 as an ATPase assembly gene
PMID:18953340
TMEM70 is involved in mitochondrial ATP synthase biogenesis
→ Oxidative Phosphorylation@Mitochondrial inner membrane
→ ATP5B@Mitochondrial inner membrane
+ ATP5B@Mitochondrial inner membrane + ATP5G*@Mitochondrial inner membrane + ATP5C1@Mitochondrial inner membrane + MT-ATP6@Mitochondrial inner membrane + MT-ATP8@Mitochondrial inner membrane → ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E:ATP5F1:ATP5G*:ATP5H:ATP5I:ATP5J:ATP5J2:ATP5L:ATP5O:ATP5S:MT-ATP6:MT-ATP8@Mitochondrial inner membrane