Reaction state_transition rc_re979
degraded + ATP5A1@Mitochondrial inner membrane
+ ATP5B@Mitochondrial inner membrane
+ ATP5G*@Mitochondrial inner membrane
+ ATP5C1@Mitochondrial inner membrane
+ MT-ATP6@Mitochondrial inner membrane
+ MT-ATP8@Mitochondrial inner membrane
→ ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E:ATP5F1:ATP5G*:ATP5H:ATP5I:ATP5J:ATP5J2:ATP5L:ATP5O:ATP5S:MT-ATP6:MT-ATP8@Mitochondrial inner membrane
Reaction regulators:
- Catalysis
- ATPAF1@Mitochondrial inner membrane
- ATPAF2@Mitochondrial inner membrane
- TMEM70@Mitochondrial inner membrane
References
PMID:11410595
ATPAF1 role in assembly of mitochondrial ATP synthase inferred from yeast, on the basis that ATPAF1 interacts with ATP5B (Y2H) and complements the yeast mutant
similar function suggested for ATPAF2
PMID:14701807
in vitro, human ATPAF2 functions as a protein chaperone
PMID:14757859
a mutation found in gene ATPAF2 from a patient with mitochondrial encephalomyopathies supports the role of ATPAF2 as an ATPase assembly gene
PMID:18953340
TMEM70 is involved in mitochondrial ATP synthase biogenesis