CTSB

Protein CTSB

Identifiers
cathepsin B
HUGO:CTSB HGNC:2527 ENTREZ:1508 UNIPROT:P07858
HUGO:CTSB

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
Regulated Cell Death / APOPTOSIS
Regulated Cell Death / DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death / MITOCHONDRIAL_METABOLISM
Regulated Cell Death / MOMP_REGULATION
Regulated Cell Death / NECROPTOSIS
Regulated Cell Death / PORPHYRIN_METABOLISM

References
synonym:cathepsins
DENDRITIC_CELL
PMID:16237087
CTSD (aspartic cathepsin D) and CTSG (cathepsin G) participate in antigen processing in DC.
PMID:12776207
Cathepsins B,D,L, S and AEP (LGMN) are the lysosomal proteases implicated in antigen presentation in DC.

CTSB@Mitochondrial intermembrane space

References
rc_re723( Regulated Cell Death ):
PMID:15775970
AIF as an inner membrane protein that is cleaved and released into the intermembrane space upon apoptosis induction
PMID:15590628
calpain 1 mediated processing
PMID:15933737
cathepsins and calpain 1
PMID:11278689
flavin not necessary for apoptotic function

CTSB@Lysosome

CTSB|Modification in lysosome @Lysosome

References
rc_re1162:( Regulated Cell Death ) reactionType:is.a

CTSB|Modification in lysosome @Cytosol

References
rc_re514( Regulated Cell Death ):
PMID:11940658
in vitro cleavage of BID by m-calpain
in human metastatic melanoma cell line, 224, in CASP3 deficient MCF-7 breast carcinoma cells, cleavage of BID by calpains and apoptosis in response to cisplatin
use of calpain inhibitors
involvment of mu-calpain cannot be ruled out
PMID:11404357
in rabbit heart mounted onto a Langendorff's perfusion apparatus, upon ischemia/reperfusion, cleavage of BID by calpains
in vitro cleavage of BID by recombinant mu-calpain
PMID:17264306
in human neutrophils, upon bacteria-induced lysosomal permeabilization, BID cleavage and apoptosis are reversed by cathepsin but not caspase inhibition
PMID:18469004
in different human cell lines (HeLa, MCF-7, SH-SY5Y, HaCaT, CaCo-2,HepG2), upon LeuLeuOMe-induced lysosomal membrane permeabilisation, cleavage of Bid and apoptosis, rescued by E-64d cathepsin inhibitor

CTSB@Cytosol

References
rc_re1617( Regulated Cell Death ):
PMID:18955971
LMP causes the proteolytic activation of Bid (which is cleaved by the two lysosomal cathepsins B and D), which then induces MOMP
PMID:16966373
PMID:17670831
rc_re1620( Regulated Cell Death ):
PMID:9727492
in vitro cleavage of BID by CASP8 and GZMB, BID poor substrate for CASP3
in Jurkat cleavage of BID by CASP8 upon Fas stimulation
in Hela exposed to TNF+CHX cleavage of BID by CASP8
PMID:10805722
in vitro cleavage of in vitro translated BID by purified granzyme B
in Jurkat cells exposed to GZMB+adenovirus, BID cleavage occurs independently of caspases (zVAD-fmk)
PMID:11085743
in Jurkat cells exposed to GZMB+perforin, Bcl2 over-expression mediated cell protection is abrogated by over-over-expression of BID (wt or CASP8-uncleavable mutant) but of D75 (GZMB in vitro cleavage site) mutant
PMID:11085742
in Jurkat cells exposed to GZMB+adenovirus+zVAD-fmk, BID is cleaved and localizes to mitochondria
PMID:10364179
cleavage of BID by CASP8 and CASP3
PMID:11832478
in vitro by CASP2

Modifications:
In compartment: Cytosol

CTSB@Cytosol
CTSB|Modification in lysosome @Cytosol

In compartment: Lysosome

CTSB@Lysosome
CTSB|Modification in lysosome @Lysosome

In compartment: Mitochondrial intermembrane space

CTSB@Mitochondrial intermembrane space

In compartment: PHAGOSOME/ENDOSOME/LYSOSOME_Membrane

CTSB@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane

Participates in complexes:

Participates in reactions:
As Reactant or Product:

As Catalyser: