Reaction state_transition rc_re514 map

BID|​unk@Cytosol map → cleaved_BID*@Cytosol map

Reaction regulators:
Boolean_logic_gate_or
  1. rc_s7166 and CAPN2:​Ca2+_@Cytosol map and CTSB|​Modification in lysosome @Cytosol map
Catalysis
  1. CTSB|​Modification in lysosome @Cytosol map
  2. rc_s7166
  3. CAPN2:​Ca2+_@Cytosol map


References
PMID:11940658
in vitro cleavage of BID by m-calpain
in human metastatic melanoma cell line, 224, in CASP3 deficient MCF-7 breast carcinoma cells, cleavage of BID by calpains and apoptosis in response to cisplatin
use of calpain inhibitors
involvment of mu-calpain cannot be ruled out
PMID:11404357
in rabbit heart mounted onto a Langendorff's perfusion apparatus, upon ischemia/reperfusion, cleavage of BID by calpains
in vitro cleavage of BID by recombinant mu-calpain
PMID:17264306
in human neutrophils, upon bacteria-induced lysosomal permeabilization, BID cleavage and apoptosis are reversed by cathepsin but not caspase inhibition
PMID:18469004
in different human cell lines (HeLa, MCF-7, SH-SY5Y, HaCaT, CaCo-2,HepG2), upon LeuLeuOMe-induced lysosomal membrane permeabilisation, cleavage of Bid and apoptosis, rescued by E-64d cathepsin inhibitor